Deimination, Intermediate Filaments and Associated Proteins

International Journal of Molecular Sciences

Marie-Claire Méchin¹  Julie Briot¹  Michel Simon¹ 

[1] UDEAR, Institut National de la Santé Et de la Recherche Médicale, Université Toulouse III Paul Sabatier, Université Fédérale de Toulouse Midi-Pyrénées, U1056, 31059 Toulouse, France;

关键词: citrullination;    post-translational modification;    cytoskeleton;    keratin;    filaggrin;    peptidylarginine deiminase;   

DOI  :  10.3390/ijms21228746

来源: DOAJ

【 摘 要 】

Deimination (or citrullination) is a post-translational modification catalyzed by a calcium-dependent enzyme family of five peptidylarginine deiminases (PADs). Deimination is involved in physiological processes (cell differentiation, embryogenesis, innate and adaptive immunity, etc.) and in autoimmune diseases (rheumatoid arthritis, multiple sclerosis and lupus), cancers and neurodegenerative diseases. Intermediate filaments (IF) and associated proteins (IFAP) are major substrates of PADs. Here, we focus on the effects of deimination on the polymerization and solubility properties of IF proteins and on the proteolysis and cross-linking of IFAP, to finally expose some features of interest and some limitations of citrullinomes.

【 授权许可】

Unknown