Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA)

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

Heather Snyder¹  Scott Miners²  Ajay Verma³  Maya Koronyo‐Hamaoui⁴  Brian J. Bacskai⁵  Susanne J. vanVeluw⁵  Alt Clemens⁵  Steven M. Greenberg⁵  Nivedita Agarwal⁶  Gesine Paul⁷  Guojun Bu⁸  Edith Hamel⁹  Scott E. Counts^1,10  Satoshi Saito^1,11  Masafumi Ihara^1,11  Henrieta Scholtzova^1,12  Raj N. Kalaria^1,13  Steven M. Rich^1,14  Roxana Aldea^1,15  Andy Shih^1,16  Atticus H. Hainsworth^1,17  David J. Werring^1,18  JoAnne McLaurin^1,19  Silvia Fossati^2,20  Finnbogi Rutur Thormodsson^2,21  Ville Leinonen^2,22  Katja M. Kanninen^2,22  Tarja Malm^2,22  Donna Wilcock^2,23  Cheryl A. Hawkes^2,24  Ingo Bechman^2,25  Fabrizio Piazza^2,26  Per K. Eide^2,27  Peter Snyder^2,28  James A. R. Nicoll^2,29  Roxana O. Carare^2,29  Christopher M. Kipps^2,29  Roy O. Weller^2,29  Delphine Boche^2,29  Diederik Bulters^2,29  Berislav V. Zlokovic^3,30  Mark R. Wilson^3,31  Angela Jefferson^3,32  David Holtzman^3,33  Mony deLeon^3,34 

[1] Alzheimer's Association Chicago Illinois USA;Bristol University Bristol UK;CODIAK Biosciences Cambridge Massachusetts USA;Cedars‐Sinai Medical Center Los Angeles California USA;Harvard University Cambridge Massachusetts USA;Hospital Santa Maria del Carmine Rovereto Italy;Lund University Lund Sweden;Mayo Clinic Jacksonville Florida USA;McGill University Montreal Canada;Michigan State University East Lansing Michigan USA;National Cerebral and Cardiovascular Center Osaka Japan;New York University New York New York USA;Newcastle University Tyne UK;QAAM Pharmaceuticals LLC Canandaigua New York USA;Roche Innovation Center Basel Basel Switzerland;Seattle Children's Hospital Seattle Washington USA;St George's University of London London UK;Stroke Research Centre UCL Queen Square Institute of Neurology University College London London UK;Sunnybrook Research Institute Toronto Ontario Canada;Temple University Philadelphia Pennsylvania USA;University of Akureyri Akureyri Iceland;University of Eastern Finland Kuopio Finland;University of Kentucky Lexington Kentucky USA;University of Lancaster Lancashire UK;University of Leipzig Leipzig Germany;University of Milano ‐ Bicocca Monza Italy;University of Oslo Oslo Norway;University of Rhode Island South Kingstown Rhode Island USA;University of Southampton Southampton UK;University of Southern California Los Angeles California USA;University of Wollongong Wollongong Australia;Vanderbilt University Nashville Tennessee USA;Washington University St Louis St. Louis Missouri USA;Weill Cornell Medicine New York USA;

关键词: cerebrospinal fluid;    clearance;    interstitial fluid;    IPAD;    ISTAART;   

DOI  :  10.1002/dad2.12053

来源: DOAJ

【 摘 要 】

Abstract Two of the key functions of arteries in the brain are (1) the well‐recognized supply of blood via the vascular lumen and (2) the emerging role for the arterial walls as routes for the elimination of interstitial fluid (ISF) and soluble metabolites, such as amyloid beta (Aβ), from the brain and retina. As the brain and retina possess no conventional lymphatic vessels, fluid drainage toward peripheral lymph nodes is mediated via transport along basement membranes in the walls of capillaries and arteries that form the intramural peri‐arterial drainage (IPAD) system. IPAD tends to fail as arteries age but the mechanisms underlying the failure are unclear. In some people this is reflected in the accumulation of Aβ plaques in the brain in Alzheimer's disease (AD) and deposition of Aβ within artery walls as cerebral amyloid angiopathy (CAA). Knowledge of the dynamics of IPAD and why it fails with age is essential for establishing diagnostic tests for the early stages of the disease and for devising therapies that promote the clearance of Aβ in the prevention and treatment of AD and CAA. This editorial is intended to introduce the rationale that has led to the establishment of the Clearance of Interstitial Fluid (ISF) and CSF (CLIC) group, within the Vascular Professional Interest Area of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment.

【 授权许可】

Unknown