Glymphatic system impairment in nonathlete older male adults who played contact sports in their youth associated with cognitive decline: A diffusion tensor image analysis along the perivascular space study

Frontiers in Neurology

Neurology

Mari Miyata¹  Toshiaki Taoka²  Hitoshi Naito³  Hideyoshi Kaga³  Yuya Saito⁴  Koji Kamagata⁴  Wataru Uchida⁴  Shigeki Aoki⁴  Kaito Takabayashi⁴  Junko Kikuta⁴  Toshiaki Akashi⁴  Akihiko Wada⁴  Shohei Fujita⁵  Yuichi Morita⁵  Christina Andica⁶  Shinji Naganawa⁷  Osamu Abe⁸  Thomas Samoyeau⁹  Hiroki Tabata^1,10  Yoshifumi Tamura^1,11  Hirotaka Watada^1,11  Ryuzo Kawamori^1,11  Yuki Someya^1,12 

[1] Department of Functional Brain Imaging, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan;Department of Innovative Biomedical Visualization, Graduate School of Medicine, Nagoya University, Nagoya, Japan;Department of Metabolism and Endocrinology, Graduate School of Medicine, Juntendo University, Tokyo, Japan;Department of Radiology, Graduate School of Medicine, Juntendo University, Tokyo, Japan;Department of Radiology, Graduate School of Medicine, Juntendo University, Tokyo, Japan;Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;Department of Radiology, Graduate School of Medicine, Juntendo University, Tokyo, Japan;Faculty of Health Data Science, Juntendo University, Chiba, Japan;Department of Radiology, Graduate School of Medicine, Nagoya University, Nagoya, Japan;Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;Department of Radiology, Necker Hospital, Paris University, Paris, France;Sportology Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan;Sportology Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan;Department of Metabolism and Endocrinology, Graduate School of Medicine, Juntendo University, Tokyo, Japan;Sportology Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan;Graduate School of Health and Sports Science, Juntendo University, Inzai, Chiba, Japan;

关键词: repetitive head impacts;    contact sports;    glymphatic system;    DTI-ALPS;    diffusion-weighted imaging;    cerebrospinal fluid;    interstitial fluid;   

DOI  :  10.3389/fneur.2023.1100736

 received in 2022-11-17, accepted in 2023-01-09,  发布年份 2023

来源: Frontiers

【 摘 要 】

Background and purposeExposure to contact sports in youth causes brain health problems later in life. For instance, the repetitive head impacts in contact sports might contribute to glymphatic clearance impairment and cognitive decline. This study aimed to assess the effect of contact sports participation in youth on glymphatic function in old age and the relationship between glymphatic function and cognitive status using the analysis along the perivascular space (ALPS) index.Materials and methodsA total of 52 Japanese older male subjects were included in the study, including 12 who played heavy-contact sports (mean age, 71.2 years), 15 who played semicontact sports (mean age, 73.1 years), and 25 who played noncontact sports (mean age, 71.3 years) in their youth. All brain diffusion-weighted images (DWIs) of the subjects were acquired using a 3T MRI scanner. The ALPS indices were calculated using a validated semiautomated pipeline. The ALPS indices from the left and right hemispheres were compared between groups using a general linear model, including age and years of education. Furthermore, partial Spearman's rank correlation tests were performed to assess the correlation between the ALPS indices and cognitive scores (Mini-Mental State Examination and the Japanese version of the Montreal Cognitive Assessment [MoCA-J]) after adjusting for age years of education and HbA1c.ResultsThe left ALPS index was significantly lower in the heavy-contact and semicontact groups than that in the noncontact group. Although no significant differences were observed in the left ALPS index between the heavy-contact and semicontact groups and in the right ALPS index among groups, a trend toward lower was found in the right ALPS index in individuals with semicontact and heavy-contact compared to the noncontact group. Both sides' ALPS indices were significantly positively correlated with the MoCA-J scores.ConclusionThe findings indicated the potential adverse effect of contact sports experience in youth on the glymphatic system function in old age associated with cognitive decline.

【 授权许可】

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Copyright © 2023 Morita, Kamagata, Andica, Takabayashi, Kikuta, Fujita, Samoyeau, Uchida, Saito, Tabata, Naito, Someya, Kaga, Tamura, Miyata, Akashi, Wada, Taoka, Naganawa, Watada, Kawamori, Abe and Aoki.