CERN-MEDICIS: A Review Since Commissioning in 2017

Frontiers in Medicine

the CERN-MEDICIS collaboration¹  Frank Bruchertseifer²  Robert Formento-Cavaier³  Ferid Haddad³  Nathalie Michel³  Nadia Audouin³  Ulli Köster⁴  Vadim M. Gadelshin⁵  Klaus Wendt⁵  Charlotte Duchemin⁶  Kristof Dockx⁶  Joao P. Ramos⁶  Yisel Martinez Palenzuela⁶  Essraa Ahmed⁶  Reinhard Heinke⁶  Thomas E. Cocolios⁶  Simon Stegemann⁶  Peter Ivanov⁷  Ben Russell⁷  Benjamin Webster⁷  Valentin N. Fedosseev⁸  Katerina Chrysalidis⁸  Jean-Yves Rinchet⁸  Christelle Saury⁸  Jeremie Comte⁸  Ana-Paula Bernardes⁸  Nabil Menaa⁸  Maxime Munos⁸  Heinz Vincke⁸  Jean-Louis Grenard⁸  Bernard Crepieux⁸  Thomas Schneider⁸  SafouaneEl Idrissi⁸  Giacomo Lunghi⁸  Christian Theis⁸  Julien Riegert⁸  Benjamin Juif⁸  Elodie Aubert⁸  Vincent Barozier⁸  Renata Martins⁸  Nhat-Tan Vuong⁸  Fabio Pozzi⁸  Pinelopi Christodoulou⁸  Matthieu Deschamps⁸  Alexandre Dorsival⁸  Simone Gilardoni⁸  Ermanno Barbero⁸  Miranda van Stenis⁸  Joachim Vollaire⁸  Thierry Stora⁸  Aurore Boscher⁸  Francesco Riccardi⁸  Shane G. Wilkins⁸  Stefano Marzari⁸  Eric Chevallay⁸  Nicolas Riggaz⁸  Pascal Fernier⁸  Sebastian Rothe⁸  Richard Catherall⁸  Philippe Bertreix⁸  Bruce A. Marsh⁸  Laura Lambert⁸  Julien Thiboud⁸  G. Lilli⁸  Moazam Khan⁹  Umair Khalid⁹  Nicholas P. van der Meulen^1,10  Zeynep Talip^1,10 

[1] ;European Commission, Joint Research Centre, Nuclear Safety and Security, Karlsruhe, Germany;Groupement d'Intérêt Public ARRONAX, Nantes, France;Institut Laue Langevin, Grenoble, France;Johannes Gutenberg University, Mainz, Germany;Katholieke Universiteit (KU) Leuven, Institute for Nuclear and Radiation Physics, Leuven, Belgium;National Physical Laboratory, Teddington, United Kingdom;Organisation Européenne pour la Recherche Nucléaire (CERN), Geneva, Switzerland;Pakistan Institute of Nuclear Science and Technology, Islamabad, Pakistan;Paul Scherrer Institute, Villigen, Switzerland;

关键词: CERN;    MEDICIS;    medical;    radionuclides;    mass separation;   

DOI  :  10.3389/fmed.2021.693682

来源: DOAJ

【 摘 要 】

The CERN-MEDICIS (MEDical Isotopes Collected from ISolde) facility has delivered its first radioactive ion beam at CERN (Switzerland) in December 2017 to support the research and development in nuclear medicine using non-conventional radionuclides. Since then, fourteen institutes, including CERN, have joined the collaboration to drive the scientific program of this unique installation and evaluate the needs of the community to improve the research in imaging, diagnostics, radiation therapy and personalized medicine. The facility has been built as an extension of the ISOLDE (Isotope Separator On Line DEvice) facility at CERN. Handling of open radioisotope sources is made possible thanks to its Radiological Controlled Area and laboratory. Targets are being irradiated by the 1.4 GeV proton beam delivered by the CERN Proton Synchrotron Booster (PSB) on a station placed between the High Resolution Separator (HRS) ISOLDE target station and its beam dump. Irradiated target materials are also received from external institutes to undergo mass separation at CERN-MEDICIS. All targets are handled via a remote handling system and exploited on a dedicated isotope separator beamline. To allow for the release and collection of a specific radionuclide of medical interest, each target is heated to temperatures of up to 2,300°C. The created ions are extracted and accelerated to an energy up to 60 kV, and the beam steered through an off-line sector field magnet mass separator. This is followed by the extraction of the radionuclide of interest through mass separation and its subsequent implantation into a collection foil. In addition, the MELISSA (MEDICIS Laser Ion Source Setup At CERN) laser laboratory, in service since April 2019, helps to increase the separation efficiency and the selectivity. After collection, the implanted radionuclides are dispatched to the biomedical research centers, participating in the CERN-MEDICIS collaboration, for Research & Development in imaging or treatment. Since its commissioning, the CERN-MEDICIS facility has provided its partner institutes with non-conventional medical radionuclides such as Tb-149, Tb-152, Tb-155, Sm-153, Tm-165, Tm-167, Er-169, Yb-175, and Ac-225 with a high specific activity. This article provides a review of the achievements and milestones of CERN-MEDICIS since it has produced its first radioactive isotope in December 2017, with a special focus on its most recent operation in 2020.

【 授权许可】

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