CERN-MEDICIS: A Review Since Commissioning in 2017

Frontiers in Medicine

article

Charlotte Duchemin¹  Philippe Bertreix¹  Aurore Boscher¹  Frank Bruchertseifer³  Richard Catherall¹  Eric Chevallay¹  Pinelopi Christodoulou¹  Katerina Chrysalidis¹  Thomas E. Cocolios²  Jeremie Comte¹  Bernard Crepieux¹  Joao P. Ramos¹  Matthieu Deschamps¹  Kristof Dockx²  Alexandre Dorsival¹  Valentin N. Fedosseev¹  Pascal Fernier¹  Robert Formento-Cavaier¹  Safouane El Idrissi¹  Peter Ivanov⁵  Vadim M. Gadelshin¹  Simone Gilardoni¹  Thierry Stora¹  Jean-Louis Grenard¹  Ferid Haddad⁴  Reinhard Heinke¹  Benjamin Juif¹  Umair Khalid¹  Moazam Khan¹  Ulli Köster⁸  Laura Lambert¹  G. Lilli¹  Giacomo Lunghi¹  Essraa Ahmed²  Bruce A. Marsh¹  Yisel Martinez Palenzuela²  Renata Martins¹  Stefano Marzari¹  Nabil Menaa¹  Nathalie Michel⁴  Maxime Munos¹  Fabio Pozzi¹  Francesco Riccardi¹  Julien Riegert¹  Elodie Aubert¹  Nicolas Riggaz¹  Jean-Yves Rinchet¹  Sebastian Rothe¹  Ben Russell⁵  Christelle Saury¹  Thomas Schneider¹  Simon Stegemann¹  Zeynep Talip⁹  Christian Theis¹  Julien Thiboud¹  Nadia Audouin⁴  Nicholas P. van der Meulen⁹  Miranda van Stenis¹  Heinz Vincke¹  Joachim Vollaire¹  Nhat-Tan Vuong¹  Benjamin Webster⁵  Klaus Wendt⁶  Shane G. Wilkins¹  Ermanno Barbero¹  Vincent Barozier¹  Ana-Paula Bernardes¹ 

[1] Organisation Européenne pour la Recherche Nucléaire (CERN);Katholieke Universiteit (KU) Leuven, Institute for Nuclear and Radiation Physics;Joint Research Centre;Groupement d'Intérêt Public ARRONAX;National Physical Laboratory, United Kingdom;Johannes Gutenberg University;Pakistan Institute of Nuclear Science and Technology;Institut Laue Langevin;Paul Scherrer Institute

关键词: CERN;    MEDICIS;    medical;    radionuclides;    mass separation;   

DOI  :  10.3389/fmed.2021.693682

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

The CERN-MEDICIS (MEDical Isotopes Collected from ISolde) facility has delivered its first radioactive ion beam at CERN (Switzerland) in December 2017 to support the research and development in nuclear medicine using non-conventional radionuclides. Since then, fourteen institutes, including CERN, have joined the collaboration to drive the scientific program of this unique installation and evaluate the needs of the community to improve the research in imaging, diagnostics, radiation therapy and personalized medicine. The facility has been built as an extension of the ISOLDE (Isotope Separator On Line DEvice) facility at CERN. Handling of open radioisotope sources is made possible thanks to its Radiological Controlled Area and laboratory. Targets are being irradiated by the 1.4 GeV proton beam delivered by the CERN Proton Synchrotron Booster (PSB) on a station placed between the High Resolution Separator (HRS) ISOLDE target station and its beam dump. Irradiated target materials are also received from external institutes to undergo mass separation at CERN-MEDICIS. All targets are handled via a remote handling system and exploited on a dedicated isotope separator beamline. To allow for the release and collection of a specific radionuclide of medical interest, each target is heated to temperatures of up to 2,300°C. The created ions are extracted and accelerated to an energy up to 60 kV, and the beam steered through an off-line sector field magnet mass separator. This is followed by the extraction of the radionuclide of interest through mass separation and its subsequent implantation into a collection foil. In addition, the MELISSA (MEDICIS Laser Ion Source Setup At CERN) laser laboratory, in service since April 2019, helps to increase the separation efficiency and the selectivity. After collection, the implanted radionuclides are dispatched to the biomedical research centers, participating in the CERN-MEDICIS collaboration, for Research & Development in imaging or treatment. Since its commissioning, the CERN-MEDICIS facility has provided its partner institutes with non-conventional medical radionuclides such as Tb-149, Tb-152, Tb-155, Sm-153, Tm-165, Tm-167, Er-169, Yb-175, and Ac-225 with a high specific activity. This article provides a review of the achievements and milestones of CERN-MEDICIS since it has produced its first radioactive isotope in December 2017, with a special focus on its most recent operation in 2020.

【 授权许可】

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