JUUL™ing and Heating Lead to a Worsening of Arterial Stiffness

Medicines

Moritz Meusel¹  Ingo Eitel¹  Klaas F. Franzen²  Julia Benthien²  Daniel Drömann²  Silja Cayo Talavera² 

[1] Medical Clinic II, Campus Lübeck, University Hospital Schleswig-Holstein, 23562 Lübeck, Germany;Medical Clinic III, Campus Lübeck, University Hospital Schleswig-Holstein, 23562 Lübeck, Germany;

关键词: arterial stiffness;    endothelial dysfunction;    JUUL;    HTP;    cigarette;    e-cigarette;   

DOI  :  10.3390/medicines9040028

来源: DOAJ

【 摘 要 】

Background: The widespread use of the JUUL™ device ignited a discussion about the effects these products have on harm reduction. Therefore, we conducted a study directly comparing the JUUL™ device with a cigarette, a heated tobacco product, and a nicotine-free e-cigarette to examine the acute effects on arterial stiffness. Methods: This crossover-designed study examines 20 occasional smokers (age 25.2 ± 2.5 years). Study participants used each of the four smoking devices for a duration of 5 min following a protocol. Peripheral blood pressure and parameters of arterial stiffness and endothelial vasodilator function such as the reactive hyperemia index and the augmentation index were measured using the EndoPAT™2000 before and after. Results: In addition to significant peripheral hemodynamic changes after 5 and 10 min (p < 0.05), the reactive hyperemia index showed a significant decrease for all devices 15 min after consumption and remained significantly decreased after 60 min (p < 0.01). The augmentation index adjusted for a heart rate of 75 bpm increased significantly for all devices 15 and 60 min after consumption (p < 0.01). Conclusions: In conclusion, the increases in blood pressure and arterial stiffness are similar after smoking, JUUL™ing, heating, and vaping. These changes may be associated with an increase in cardiovascular risks; however, an evaluation of the long-term effects of JUUL™ing, vaping and heating is needed.

【 授权许可】

Unknown