Case Report: Changes of Vascular Reactivity and Arterial Stiffness in a Patient With Covid-19 Infection

Frontiers in Cardiovascular Medicine

Harald H. Kessler¹  Philipp Jud²  Marianne Brodmann² 

[1] Diagnostic and Research Institute of Hygiene, Microbiology, and Environmental Medicine, Medical University of Graz, Graz, Austria;Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria;

关键词: Covid-19;    endothelial dysfunction;    vascular reactivity;    arterial stiffness;    vasculopathy;   

DOI  :  10.3389/fcvm.2021.671669

来源: Frontiers

【 摘 要 】

Covid-19 infection may be associated with a higher incidence developing cardiovascular complications, however, the underlying mechanisms contributing to cardiovascular complications are largely unknown, while endothelial cell damage may be present. We want to report a 24-year-old woman with Covid-19 infection who had undergone measurements of vascular reactivity and arterial stiffness, including flow-mediated dilation (FMD), nitroglycerin-mediated dilation (NMD), aortic pulse wave velocity (PWV), augmentation index and carotid intima-media-thickness (cIMT) at the time when Covid-19 was diagnosed. Reduced FMD of 0.0% and NMD of 15.5% were observed, while PWV (5.9 m/s), Aix (27%) and cIMT with 0.4 mm of both common carotid arteries were unremarkable. Repeated measurements of FMD, NMD, PWV, Aix, and cIMT 6 weeks after Covid-19 infection revealed persistently reduced FMD (0.0%), while NMD (17.24%), PWV (5.6 m/s) and augmentation index (13%) ameliorated. This case suggests potential impact of Covid-19 infection on endothelial function, also in young Covid-19 patients without any co-morbidity.

【 授权许可】

CC BY