A comprehensive strategy for the early treatment of COVID-19 with azithromycin/hydroxychloroquine and/or corticosteroids: Results of a retrospective observational study in the French overseas department of Réunion Island

Journal of Global Antimicrobial Resistance

Marie Lagrange-Xelot¹  Emilie Foch²  Vincent Thomas³  Diane Moreau⁴  Adrien Maillot⁵  Loic Raffray⁶  Loraine Gauzere⁶  Karine Borsu⁷  Servane Dibernardo⁷  Stéphane Renaud⁸  Michel André⁸  Nathalie Coolen-Allou⁹  Arthur Dubernet⁹  Kevin Larsen⁹  Julien Jabot⁹  Lea Bruneau⁹  Laurie Masse⁹  Jérôme Allyn^1,10  Nicolas Allou^1,10  Marie-Christine Jaffar-Bandjee^1,11 

[1] Department of Public Health and Research Support, Methodological Support and Biostatistics Unit, University Hospital, Saint Denis, Réunion Island, France;Département d’Informatique Clinique, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France;Department of Public Health and Research Support, Methodological Support and Biostatistics Unit, University Hospital, Saint Denis, Réunion Island, France;Gériatrie, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France;INSERM CIC 1410 Clinical and Epidemiology, University Hospital, Saint Pierre, Réunion Island, France;Microbiologie, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France;Médecine Interne, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France;Médecine Polyvalente, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France;Pneumologie, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France;Réanimation polyvalente, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France;Service des Maladies Infectieuses, Centre Hospitalier Universitaire Felix-Guyon, Allée des Topazes, 97405 Saint Denis, Réunion Island, France;

关键词: COVID-19;    SARS-CoV-2;    Hydroxychloroquine;    Azithromycin;    Corticosteroids;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: This study aimed to evaluate the prognosis of COVID-19 patients in Reunion Island, with a particular focus on the management of patients with hypoxemic pneumonia. Methods: This retrospective observational study was conducted from 11 March to 17 April 2020 at the only hospital authorized to manage patients with COVID-19 in Reunion Island. Results: Over the study period, 164 out of 398 patients (41.2%) infected with COVID-19 were admitted to Félix Guyon University Hospital. Of these, 36 (22%) developed hypoxemic pneumonia. Patients with hypoxemic pneumonia were aged 66 [56–77] years, 69% were male and 33% had hypertension. Ten patients (27.8%) were hospitalized in intensive care unit (ICU). Hydroxychloroquine/azithromycin treatment was associated with a lower ICU admission rate (P = 0.008). None of the 6 patients treated with corticosteroids were hospitalized in ICU (P = 0.16). There were no deaths at follow up (minimum 80 days). Conclusions: Despite the risk profile of COVID-19 patients with severe hypoxemic pneumonia, the mortality rate of the disease in Reunion Island was 0%. This may be due to the care bundle used in our hospital (early hospitalisation, treatment with hydroxychloroquine/azithromycin and/or corticosteroids, non-invasive respiratory support, etc).

【 授权许可】

Unknown