Effect of oligonol, a lychee‐derived polyphenol, on skeletal muscle in ovariectomized rats by regulating body composition, protein turnover, and mitochondrial quality signaling

Food Science & Nutrition

Hyangkyu Lee¹  Jeong Hun Kim²  Yun Kyung Jeon³  Keunyoung Kim⁴  In‐Joo Kim⁴  Kyoungjune Pak⁴  Byung‐Joo Lee⁵  Ji Min Kim⁶ 

[1] Biobehavioral Research Centre Mo‐Im Kim Nursing Research Institute College of Nursing Yonsei University Seoul Korea;Biomedical Research Institute Pusan National University Hospital Busan Korea;Department of Internal Medicine and Biomedical Research Institute Pusan National University Hospital Busan Korea;Department of Nuclear Medicine and Biomedical Research Institute Pusan National University Hospital Busan Korea;Department of Otorhinolaryngology‐Head and Neck Surgery Pusan National University School of Medicine Pusan National University Busan Korea;Pusan National University Medical Research Institute Pusan National University School of Medicine Pusan National University Yangsan Korea;

关键词: body composition;    mitochondrial dynamics;    ovariectomy;    polyphenols;    skeletal muscle;   

DOI  :  10.1002/fsn3.2750

来源: DOAJ

【 摘 要 】

Abstract Oligonol is a low‐molecular‐weight polyphenol product derived from lychee (Litchi chinensis Sonn.) fruits. This study was focused on the effects of oligonol on the skeletal muscle of ovariectomized rats. We randomly divided female Sprague–Dawley rats into three groups: a sham surgery control group (Sham), an ovariectomy (OVX) group, and an OVX group treated with oligonol (OVX + Oligonol). Oligonol was intraperitoneally administrated at 30 mg/kg daily for 6 weeks. Oligonol treatment after OVX decreased body weight and fat mass, regulated lipid metabolism in skeletal muscle, without loss of lean mass and bone. Bone turnover was not affected by oligonol. In protein synthesis and degradation, oligonol increased the levels of the mammalian target of rapamycin and its downstream targets, eukaryotic initiation factor 4E‐binding protein 1 and 70‐kDa ribosomal protein S6 kinase, and it stimulated the expression of ubiquitin‐proteasome pathway proteins, the forkhead box transcription factors of the class O and the muscle ring‐finger protein‐1. Moreover, oligonol treatment enhanced mitochondrial biogenesis and dynamics. Thus, our results indicated that oligonol treatment had beneficial effects on the skeletal muscle in an estrogen‐deficiency rat model.

【 授权许可】

Unknown