Adipokines Expression and Effects in Oocyte Maturation, Fertilization and Early Embryo Development: Lessons from Mammals and Birds

International Journal of Molecular Sciences

Anthony Estienne¹  Joëlle Dupont¹  Pascal Froment¹  Adeline Brossaud¹  Christelle Ramé¹  Maxime Reverchon² 

[1] INRAE UMR 85 Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France;SYSAAF-Syndicat des Sélectionneurs Avicoles et Aquacoles Français, Centre INRAE Val de Loire, F-37380 Nouzilly, France;

关键词: oocyte maturation;    early embryo development;    adipokines;    mammals;    birds;   

DOI  :  10.3390/ijms21103581

来源: DOAJ

【 摘 要 】

Some evidence shows that body mass index in humans and extreme weights in animal models, including avian species, are associated with low in vitro fertilization, bad oocyte quality, and embryo development failures. Adipokines are hormones mainly produced and released by white adipose tissue. They play a key role in the regulation of energy metabolism. However, they are also involved in many other physiological processes including reproductive functions. Indeed, leptin and adiponectin, the most studied adipokines, but also novel adipokines including visfatin and chemerin, are expressed within the reproductive tract and modulate female fertility. Much of the literature has focused on the physiological and pathological roles of these adipokines in ovary, placenta, and uterine functions. The purpose of this review is to summarize the current knowledge regarding the involvement of leptin, adiponectin, visfatin, and chemerin in the oocyte maturation, fertilization, and embryo development in both mammals and birds.

【 授权许可】

Unknown