Nutrition & Metabolism | |
A high calcium diet containing nonfat dry milk reduces weight gain and associated adipose tissue inflammation in diet-induced obese mice when compared to high calcium alone | |
关键词: Calcitriol; calcium; dairy; obesity; inflammation; | |
DOI : 10.1186/1743-7075-9-3 | |
来源: DOAJ |
【 摘 要 】
Abstract
Background
High dietary calcium (Ca) is reported to have anti-obesity and anti-inflammatory properties. Evidence for these properties of dietary Ca in animal models of polygenic obesity have been confounded by the inclusion of dairy food components in experimental diets; thus, effect of Ca
Methods
We characterized adiposity along with metabolic and inflammatory phenotypes in diet-induced obese (DIO) mice fed 1 of 3 high fat diets (45% energy) for 12 wk: control (
Results
Mice fed high-Ca + NFDM had reduced body weight and adiposity compared to high-Ca mice (
Conclusions
The results indicate that high dietary Ca is not sufficient to dampen obesity-related phenotypes in DIO mice, and in fact exacerbates weight gain and hyperphagia. The data further suggest that putative anti-obesity properties of dairy emanate from food components beyond Ca.
【 授权许可】
Unknown