An Overview on Synthesis and Functionalization of Mesoporous Silica and Its Application in Drug Delivery

علوم و تکنولوژی پلیمر

Sepideh Khoee¹  Reza Bafkar¹ 

[1] Polymer Chemistry Group, Department of Chemistry, Faculty of Science, Tehran University, P.O. Box: 14155-6455, Tehran, Iran;

关键词: mesoporos silica;    grafting;    co-condensation;    periodic mesoporous organosilicate;    drug delivery;    stimuli-responsive;   

DOI  :  10.22063/jipst.2016.1378

来源: DOAJ

【 摘 要 】

Nanotechnology has a prominent potential in biomedical and biomedicine applications. Especially, owing to their exclusive characteristics, hybrid nanocompounds have been recently considered as promising systems for imaging and therapeutic usages. Study on silica-based mesoporous silica materials as drug delivery systems has been considerably developed over the recent few years due to the excellent versatility and stability of these mesoporous materials. In this review, the advanced developments in synthesis, functionalization and application of mesoporous silica in drug delivery are introduced. The first section consists of three main methods, grafting, co-condensation, and periodic mesoporous organosilicates. In the next part, new approaches for functionalization of mesoporous silica in order to control drug delivery are explained. The superiority of mesoporous nannoparticles for numerous drug delivery applications are also summarized. Different mesoporous silica structures can be designed by various chemical methods to meet the drug delivery requirements. The accessible channels in mesoporous which may act as reservoirs for storing drugs can be opened and closed by different systems and create stimuli-responsive release carriers. This review focuses on intelligent nanomaterials based on mesoporous silica which can be stimulated by chemical or biological signals, such as pH, temperature, light, magnetic field and enzymes.

【 授权许可】

Unknown