Strategies for formulation of effervescent granules of an herbal product for the management of typhoid fever

Heliyon

Godfred Egbi¹  Alexander Nyarko²  Papa Yaw Addo³  Doris Kumadoh⁴  Emmanuel Adase⁵  Ofosua Adi-Dako⁶  Christina Osei-Asare⁶  Esther Eshun Oppong⁷  Samuel Okyem⁸ 

[1] Corresponding author.;University of Illinois-Urbana Champaign, USA;Central Laboratory, Kwame Nkrumah University of Science and Technology, Ghana;Centre for Plant Medicine Research, Mampong, Akuapem, Ghana;Department of Pharmaceutical Sciences, Central University College, Ghana;Department of Pharmaceutics and Microbiology, School of Pharmacy, University of Ghana, Ghana;Department of Pharmacology and Toxicology, School of Pharmacy, University of Ghana, Ghana;Noguchi Memorial Institute for Medical Research, University of Ghana, Ghana;

关键词: Typhoid fever;    Herbal medicine;    Effervescent granules;    Formulation;    High performance liquid chromatography;   

DOI  :  

来源: DOAJ

【 摘 要 】

Herbal medicines are currently being adopted as alternatives to orthodox medicines for the management of drug-resistant and emerging multidrug-resistant microbial strains of various diseases, including typhoid fever. A herbal decoction, MA 001, manufactured by the Centre for Plant Medicine Research (CPMR), has been used for the treatment of typhoid fever for at least two decades in Ghana with desirable outcomes. MA 001 is formulated from Citrus aurantifolia, Spondias mombin, Latana camara, Bidens pilosa, Trema occidentalis, Psidium guajava, Morinda lucida, Vernonia amygdalina, Persea americana, Paulina pinnatta, Momordia charantia and Cnestis ferruguinea medicinal plants. The low palatability and compliance to treatment due to the bulky nature of the decoction poses challenges in its optimum use. This study sought to design and formulate the therapeutic components of the aqueous herbal decoction of MA 001 into an optimal solid dosage form of effervescent granules to improve the delivery of MA 001 as well as increase patient compliance and convenience of product handling. The methods involved pre-formulation studies on the suitability of effervescent vehicles, formulation and evaluation of effervescent granules for drug excipient interactions using high performance liquid chromatography analysis. The findings indicate that the effervescent granules were suitable for use in the delivery of the therapeutic constituents for the treatment of typhoid fever as done with the decoction due to minimal herbal extract-excipient interaction.

【 授权许可】

Unknown