Advances in Research on Antiviral Activities of Sulfated Polysaccharides from Seaweeds

Pharmaceuticals

Kai Ji¹  Ke Wang²  Shuliang Song²  Qiang Wei²  Jiarui Zhao²  Yuan Wang²  Qiong Yang²  Guoqiang Fu³ 

[1] Department of Plastic Surgery, China-Japan Friendship Hospital, Beijing 100029, China;Marine College, Shandong University, Weihai 264209, China;Weihaiwei People’s Hospital, Weihai 264200, China;

关键词: sulfated polysaccharides;    seaweed;    algae;    antiviral;    viruses;    SARS-CoV-2;   

DOI  :  10.3390/ph15050581

来源: DOAJ

【 摘 要 】

In recent years, various viral diseases have suddenly erupted, resulting in widespread infection and death. A variety of biological activities from marine natural products have gradually attracted the attention of people. Seaweeds have a wide range of sources, huge output, and high economic benefits. This is very promising in the pharmaceutical industry. In particular, sulfated polysaccharides derived from seaweeds, considered a potential source of bioactive compounds for drug development, have shown antiviral activity against a broad spectrum of viruses, mainly including common DNA viruses and RNA viruses. In addition, sulfated polysaccharides can also improve the body’s immunity. This review focuses on recent advances in antiviral research on the sulfated polysaccharides from seaweeds, including carrageenan, galactan, fucoidan, alginate, ulvan, p-KG03, naviculan, and calcium spirulan. We hope that this review will provide new ideas for the development of COVID-19 therapeutics and vaccines.

【 授权许可】

Unknown