Fabrication and characterization of lysine hydrochloride Cu(ii) complexes and their potential for bombing bacterial resistance

Green Processing and Synthesis

Zafar Ayesha¹  Fu Zhihuan²  Tian Yunbo²  Wu Ziqian²  Shu Xugang²  Huang Liting²  Yang Yuanting²  Li Cuijing²  Hasan Murtaza² 

[1] School of Biomedical Engineering, Department of Future Technology, Peking University, Beijing 100871, China;School of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong Province, 510225, China;

关键词: lys–cu;    synthesis;    characterization;    biocompatibility;    antimicrobial activity;   

DOI  :  10.1515/gps-2022-0043

来源: DOAJ

【 摘 要 】

The emergence of drug-resistant bacteria and the lack of effective antimicrobial agents have posed a threat to public safety, so a new efficient strategy is needed to deal with the increasing severity of bacteria. Herein, a substitute antibacterial agent with high stability and biocompatibility was synthesized by incorporating lysine hydrochloride and copper sulfate pentahydrate following the liquid-phase synthesis method. The composition and structure of the Cu(ii) complex (Lys–Cu) were characterized by performing ultraviolet-visible spectrophotometry, Fourier-transform infrared spectroscopy, X-ray diffractometry (XRD), thermogravimetric analysis-differential scanning calorimetry, and single-crystal XRD. The crystal structure of Lys–Cu belongs to a monoclinic system, space group P21, with cell parameters of a = 5.14350(10), b = 16.8308(2), c = 11.4915(2) Å, Z = 2, and D = 1.548 g·cm−3. Bacteriostatic tests were carried out on Escherichia coli and Staphylococcus aureus. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of Lys–Cu against S. aureus were 0.3125 and 0.9250 mg·mL−1, respectively. The MIC and MBC values of Lys–Cu against bacterial strain E. coli were 0.4685 and 0.9250 mg·mL−1, respectively.

【 授权许可】

Unknown