Gender-Related Aspects in Osteoarthritis Development and Progression: A Review

International Journal of Molecular Sciences

Flavio Ronzoni¹  Victor Fomin²  Berardo Di Matteo³  Alexey Lychagin³  Giuseppe Anzillotti⁴  Elizaveta Kon⁴  Eugene Kalinsky⁵  Marina Lipina⁵  Valeriy Royuk⁶  Maria Peshkova⁷  Anastasia Shpichka⁷  Peter Timashev⁷  Nastasia Kosheleva⁷ 

[1] Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, Italy;Department of Internal Medicine No. 1, Sechenov University, 119991 Moscow, Russia;Department of Traumatology, Orthopedics and Disaster Surgery, Sechenov University, 119991 Moscow, Russia;IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy;Laboratory of Clinical Smart Nanotechnologies, Sechenov University, 119991 Moscow, Russia;University Hospital No. 1, Sechenov University, 119991 Moscow, Russia;World-Class Research Center “Digital Biodesign and Personalized Healthcare”, Sechenov University, 119991 Moscow, Russia;

关键词: osteoarthritis;    cartilage;    biomechanics;    hormones;    sexual dimorphism;    sexual diversity;   

DOI  :  10.3390/ijms23052767

来源: DOAJ

【 摘 要 】

Osteoarthritis (OA) is a common degenerative joint disease treated mostly symptomatically before approaching its definitive treatment, joint arthroplasty. The rapidly growing prevalence of OA highlights the urgent need for a more efficient treatment strategy and boosts research into the mechanisms of OA incidence and progression. As a multifactorial disease, many aspects have been investigated as contributors to OA onset and progression. Differences in gender appear to play a role in the natural history of the disease, since female sex is known to increase the susceptibility to its development. The aim of the present review is to investigate the cues associated with gender by analyzing various hormonal, anatomical, molecular, and biomechanical parameters, as well as their differences between sexes. Our findings reveal the possible implications of gender in OA onset and progression and provide evidence for gaps in the current state of art, thus suggesting future research directions.

【 授权许可】

Unknown