The potential role of microbiota for controlling the spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) in neonatal population [version 1; referees: 2 approved]

F1000Research

Thibaud Delerue¹  Etienne Carbonnelle²  Jean-Ralph Zahar²  Loic de Pontual³ 

[1] Département de Microbiologie Clinique et Unité de Contrôle et de Prévention du risque Infectieux, Groupe Hospitalier Paris Seine Saint-Denis, AP-HP, 125 rue de Stalingrad, 9300 Bobigny, France;IAME, UMR 1137, Université Paris 13, Sorbonne Paris Cité, France;Service de pédiatrie, hôpital Jean-Verdier, Groupe Hospitalier Paris Seine Saint-Denis, Université Paris 13, AP-HP, 93140 Bondy, France;

关键词: Antimicrobials & Drug Resistance;    Bacterial Infections;    Immunity to Infections;    Medical Microbiology;    Nosocomial & Healthcare-Associated Infections;    Pediatric Infectious Diseases;   

DOI  :  10.12688/f1000research.10713.1

来源: DOAJ

【 摘 要 】

The spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) in the hospital and also the community is worrisome. Neonates particularly are exposed to the risk of ESBL-PE acquisition and, owing to the immaturity of their immune system, to a higher secondary risk of ESBL-PE-related infection. Reducing the risk of acquisition in the hospital is usually based on a bundle of measures, including screening policies at admission, improving hand hygiene compliance, and decreasing antibiotic consumption. However, recent scientific data suggest new prevention opportunities based on microbiota modifications.

【 授权许可】

Unknown