A maple syrup extract alters lipid metabolism in obese type 2 diabetic model mice

Nutrition & Metabolism

Shinji Okada¹  Keiko Abe¹  Tomoko Ishijima¹  Tsudoi Toyoda¹  Asuka Kamei² 

[1] Graduate School of Agricultural and Life Sciences, The University of Tokyo;Group for Food Functionality Assessment, Kanagawa Institute of Industrial Science and Technology;

关键词: Diabetes;    Lipid metabolism;    Maple syrup;    Polyphenol;   

DOI  :  10.1186/s12986-019-0403-2

来源: DOAJ

【 摘 要 】

Abstract Background Some polyphenols are known to improve the symptoms of diabetes. In the present study, we investigated the effects of a polyphenol-rich extract of maple syrup (MSx) on a diabetic mouse model. Methods KK-A y mice were fed a normal or 0.05% MSx-supplemented diet for 42 days. Body weight, food intake, serum biochemical parameters, and fecal total bile acid were measured. Gene expression of liver and epididymal white adipose tissue (WAT) and cecal microbiota were analyzed. Data were analyzed with an unpaired two-tailed Student’s t test or Welch’s t test according to the results of the F test. Results Serum low-density lipoprotein cholesterol levels were significantly reduced in mice that consumed MSx. Hepatic genes related to fatty acid degradation and cholesterol catabolism were upregulated in mice that consumed MSx. In contrast, the expression of genes related to lipid metabolism in WAT was unaffected by the intake of MSx. There were no significant differences between the two groups in terms of total bile acid level in the feces and the relative abundance of bacteria in the cecum. Conclusion Our results primarily indicate that MSx can help alleviate one of the symptoms of dyslipidemia.

【 授权许可】

Unknown