Activity of MCPIP1 RNase in tumor associated processes

Journal of Experimental & Clinical Cancer Research

Jolanta Jura¹  Agata Lichawska-Cieslar¹  Jerzy Kotlinowski¹  Katarzyna Miekus¹  Janusz Rys² 

[1] Department of General Biochemistry, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University;Department of Tumour Pathology, Maria Skłodowska-Curie Memorial Center and Institute of Oncology;

关键词: RNase;    Regnase-1;    Apoptosis;    Proliferation;    miRNA;    Transcript stability;   

DOI  :  10.1186/s13046-019-1430-6

来源: DOAJ

【 摘 要 】

Abstract The monocyte chemoattractant protein-induced protein (MCPIP) family consists of 4 members (MCPIP1–4) encoded by the ZC3h12A-D genes, which are located at different loci. The common features of MCPIP proteins are the zinc finger domain, consisting of three cysteines and one histidine (CCCH), and the N-terminal domain of the PilT protein (PilT-N-terminal domain (PIN domain)). All family members act as endonucleases controlling the half-life of mRNA and microRNA (miRNA). The best-studied member of this family is MCPIP1 (also known as Regnase-1). In this review, we discuss the current knowledge on the role of MCPIP1 in cancer-related processes. Because the characteristics of MCPIP1 as a fundamental negative regulator of immune processes have been comprehensively described in numerous studies, we focus on the function of MCPIP1 in modulating apoptosis, angiogenesis and metastasis.

【 授权许可】

Unknown