Clinical and immunological features and treatment of myasthenia gravis in the elderly (review)

Nervno-Myšečnye Bolezni

V. D. Kosachev¹  T. M. Alekseeva¹  A. N. Khalmurzina¹ 

[1] I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia;

关键词: myasthenia gravis;    elderly;    acetylcholinesterase inhibitors;    thymoma;    thymectomy;    intravenous immunoglobulins;    immunosuppressive therapy;    myasthenic crisis;   

DOI  :  10.17650/2222-8721-2016-6-3-10-16

来源: DOAJ

【 摘 要 】

A literature review on the peculiarities of the diagnosis, course and treatment of myasthenia gravis in the elderly has been done. Despite the fact that myasthenia gravis is a disease of the young and middle-aged, in recent years, several authors observe an increased incidence among the elderly. A proper diagnosis in this age group tend to cause difficulties, and concomitant diseases complicate the choice of therapeutic approach which includes: acetylcholinesterase inhibitors, steroids, immunosuppressants, intravenous immunoglobulins and plasmapheresis. Thymectomy in older age groups, except for the presence of thymoma, due to side effects and the lack of a strong evidence base, is not widely held. The question of the effectiveness and optimal therapeutic approach of myasthenia gravis in elderly patients is still not fully resolved.

【 授权许可】

Unknown