Metabolic Dysfunction and Peroxisome Proliferator-Activated Receptors (PPAR) in Multiple Sclerosis

International Journal of Molecular Sciences

Carlos Capela¹  Véronique Ferret-Sena²  Armando Sena² 

[1] Centro Hospitalar de Lisboa Central, EPE, Hospital de Santo António dos Capuchos, Departamento de Neurociências, Alameda de Santo António dos Capuchos, 1169-050 Lisboa, Portugal;Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz, Campus Universitário, Quinta da Granja, Monte de Caparica, 2819-511 Caparica, Portugal;

关键词: multiple sclerosis;    metabolism;    peroxisome proliferator-activated receptors;    immune system;    neuroinflammation;    neurodegeneration;   

DOI  :  10.3390/ijms19061639

来源: DOAJ

【 摘 要 】

Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS) probably caused, in most cases, by the interaction of genetic and environmental factors. This review first summarizes some clinical, epidemiological and pathological characteristics of MS. Then, the involvement of biochemical pathways is discussed in the development and repair of the CNS lesions and the immune dysfunction in the disease. Finally, the potential roles of peroxisome proliferator-activated receptors (PPAR) in MS are discussed. It is suggested that metabolic mechanisms modulated by PPAR provide a window to integrate the systemic and neurological events underlying the pathogenesis of the disease. In conclusion, the reviewed data highlight molecular avenues of understanding MS that may open new targets for improved therapies and preventive strategies for the disease.

【 授权许可】

Unknown