Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life

Frontiers in Immunology

Harri Lähdesmäki³  Onni Niemelä³  Svetlana Pylova³  Jorma Ilonen³  Samppa Ryhänen³  Robert Moulder³  Katriina Koski³  Matti Koski³  Taina Härkönen³  Hermie J. M. Harmsen³  Marina Isakova³  Outi Vaarala³  Janne Nieminen³  Gjalt Welling³  Kristi Alnek³  Tatyana Karapetyan³  Sergei Mokurov³  Henna Kallionpää³  Vallo Tillmann³  Raivo Uibo³  Anita Kondrashova³  Suvi M. Virtanen³  Heli Siljander³  Terhi Ruohtula³  Helena Ahlfors³  Elena Shakurova³  Essi Laajala³  Marcus C. De Goffau³  Heikki Hyöty³  Anu-Maaria Hämäläinen³  Mikael Knip³  Juliane Weber³  the DIABIMMUNE Study Group³  Aleksandr Peet³  Minna Kiviniemi³  Svetlana Markova³  Hanna Honkanen³  Sami Oikarinen³  Tiit Salum³  Natalya V. Dorshakova³  Kirsi Alahuhta³  Elena Kuzmicheva³  Riitta Lahesmaa³  Erika von Mutius³  Tatyana Varlamova³  Vladimir Petrov³  Valentina Ulich³  Anne Ormisson³  Helis Janson³  Jussi Lehtonen⁸  Janne K. Nieminen^1,11 

[1] 0Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland;1Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland;;Clinicum, University of Helsinki, Helsinki, Finland;Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and University of Tampere, Seinäjoki, Finland;Department of Pediatrics, Jorvi Hospital, Helsinki University Hospital, Espoo, Finland;Department of Pediatrics, University of Tartu and Tartu University Hospital, Tartu, Estonia;Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland;Folkhälsan Research Center, Helsinki, Finland;Immunogenetics Laboratory, University of Turku, Turku, Finland;Pediatric Research Center, Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland;

关键词: enterovirus;    rhinovirus;    regulatory T cell;    cytokine;    type 1 diabetes;   

DOI  :  10.3389/fimmu.2020.567046

来源: DOAJ

【 摘 要 】

Early childhood infections have been implicated in the development of immune-mediated diseases, such as allergies, asthma, and type 1 diabetes. We set out to investigate the immunomodulatory effects of early viral infections experienced before the age of one year on the peripheral regulatory T cell population (Treg) and circulating cytokines in a birth-cohort study of Estonian and Finnish infants. We show here a temporal association of virus infection with the expression of FOXP3 in regulatory T cells. Infants with rhinovirus infection during the preceding 30 days had a higher FOXP3 expression in Treg cells and decreased levels of several cytokines related to Th1 and Th2 responses in comparison to the children without infections. In contrast, FOXP3 expression was significantly decreased in highly activated (CD4+CD127−/loCD25+FOXP3high) regulatory T cells (TregFOXP3high) in the infants who had enterovirus infection during the preceding 30 or 60 days. After enterovirus infections, the cytokine profile showed an upregulation of Th1- and Th17-related cytokines and a decreased activation of CCL22, which is a chemokine derived from dendritic cells and associated with Th2 deviation. Our results reveal that immunoregulatory mechanisms are up-regulated after rhinovirus infections, while enterovirus infections are associated with activation of proinflammatory pathways and decreased immune regulation.

【 授权许可】

Unknown