In Vivo Animal Study of a Highly Viscous N-butyl Cyanoacrylate Medical Adhesive for Intravenous Embolization

Materials

Insoo Park¹  Jang Yong Kim²  Young Gook Koh³  Dogeun Kim³  Habeen Park³  Seoyun Lee³  Jae-Won Seo³  Wonmok Lee³ 

[1] Charm Vascular Clinic, 1814 Nambu-sunhwan-ro, Gwanak-gu, Seoul 08787, Korea;Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea;ENGAIN Co. Ltd., 700, Daewangpangyo-ro, Bundang-gu, Seongnam 13488, Gyeonggi-do, Korea;

关键词: N-butyl cyanoacrylate;    medical adhesive;    high viscosity;    vascular occlusion;    embolic agent;    heat of polymerization;   

DOI  :  10.3390/ma14133527

来源: DOAJ

【 摘 要 】

N-butyl cyanoacrylate (NBCA) is a liquid monomer that undergoes an exothermic polymerization reaction to form a solid upon initiation with hydroxyl anions. Recently, EGpresto, a highly viscous NBCA-based adhesive, has been developed for vascular-occlusion purposes. In this study, we investigated the heat of polymerization of EGpresto and compared the results with those of a low-viscosity NBCA glue. Results show that EGpresto exhibited a lower heat of polymerization (64 ± 7 °C vs. 34 ± 1 °C). This was due to its high viscosity, which resulted in a delayed polymerization time. To investigate the efficacy and safety of EGpresto for intravenous embolization, a 14 d in vivo animal test was conducted using three pigs. Five cc of EGpresto was injected into the epigastric vein of each animal. Complete postoperative vein occlusion was confirmed at 7 and 14 d by ultrasonographic visualization. After the animals were sacrificed, the operated and unoperated veins were exposed, and the injected adhesive was found without migration. During the histology, the injected adhesive was not found in the inner or outer vein walls, and the immune reactions seemed to be the only foreign-body reaction, showing that EGpresto is a non-toxic and safe intravascular embolic agent.

【 授权许可】

Unknown