Effect of N-butyl cyanoacrylate on fracture healing in segmental rat tibia fracture model

Journal of Orthopaedic Surgery and Research

Ay?e Sanem F?ratl?gil²  Bahadir Gokcen¹  Irfan Esenkaya⁴  Koray Unay⁴  Oguz Poyanli⁴  Mehmet Akif Akcal³ 

[1] Istanbul Florence Nightingale Orthopedics and Traumatology Department of Spine Center, Istanbul 34375, Turkey;Radiology Department, Balikligöl State Hospital, Urfa 63000, Turkey;Orthopaedics and Traumatology Clinic, Antalya Ataturk State Hospital, Antalya 07040, Turkey;Orthopaedics and Traumatology Clinic, Goztepe Training and Research Hospital, Medeniyet University, Istanbul 34722, Turkey

关键词: Rat;    N-butyl cyanoacrylate;    Segmental fracture;   

Others  :  1152014
DOI  :  10.1186/s13018-014-0076-5

 received in 2014-03-11, accepted in 2014-07-30,  发布年份 2014

【 摘 要 】

Background

Comminuted fractures can occur due to severe traumas. The treatment of these fractures that may cause serious morbidity and sometimes mortality is N-butyl cyanoacrylate. It has been reported that this adhesive provides sufficient rigid fixation for bone healing. This study aims to examine cyanoacrylate radiologically and histologically to determine whether it provides adequate recovery in segmental fractures. The secondary objective is to evaluate N-butyl cyanoacrylate, an adhesive material that can hold the fragments on the fracture line together following reduction.

Methods

Sixteen Sprague¿Dawley rats were divided in two groups as control (n?=?8) and experimental (n?=?8) groups. In the control group, segmental fractures were made and fixated with K-wire. In the experimental group, the same surgical procedure was applied and also fragments were stabilized with N-butyl cyanoacrylate.

Results

On the sixth week, we did not see any statistically significant difference in the radiological scoring between groups. However, the pathological scores of the control group were statistically higher than the cyanoacrylate group.

Conclusions

We found that cyanoacrylate was rapidly and easily applied in the segmental fractures but did not cause any superior radiological and clinical results compared to the control group. The cyanoacrylate had low viscosity, and it was not capable enough to fill the defects formed between osteotomy surfaces. However, it did not adversely affect fracture healing as seen in biopsies taken as a result of follow-ups.

【 授权许可】

   
2014 Akcal et al.; licensee BioMed Central Ltd.

【 图 表 】

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