4-Hydroxy-2,3-Dimethyl-2-Nonen-4-Olide Has an Inhibitory Effect on Pro-Inflammatory Cytokine Production in CpG-Stimulated Bone Marrow-Derived Dendritic Cells

Marine Drugs

Nam-Ho Lee¹  Jung-Eun Kim¹  Sang-Hee Byeon¹  Jin-Won Hyun²  Jung-Eun Koo²  Hee-Kyoung Kang²  Zahid Manzoor²  Young-Sang Koh²  Irshad Ali²  Eun-Sook Yoo² 

[1] Department of Chemistry and Cosmetics, College of Natural Sciences, Jeju National University, Jeju 690-756, Korea;School of Medicine and Brain Korea 21 PLUS Program, Jeju National University, Jeju 690-756, Korea;

关键词: 4-hydroxy-2,3-dimethyl-2-nonen-4-olide;    inflammation;    activator protein-1;    pro-inflammatory cytokine;   

DOI  :  10.3390/md14050088

来源: DOAJ

【 摘 要 】

This study was intended to assess the anti-inflammatory properties of 4-hydroxy-2,3-dimethyl-2-nonen-4-olide (Comp) isolated from Ulva pertusa Kjellman on production of pro-inflammatory cytokines. Comp revealed remarkable inhibitory effects on production of pro-inflammatory cytokines in bone marrow-derived dendritic cells (BMDCs). Comp pre-treatment in the CpG DNA-stimulated BMDCs exhibited strong inhibition of interleukin (IL)-12 p40 and IL-6 production with IC50 values ranging from 7.57 ± 0.2 to 10.83 ± 0.3, respectively. It revealed an inhibitory effect on the phosphorylation of ERK1/2, JNK1/2, and p38, and on activator protein (AP)-1 reporter activity. Comp displayed noteworthy inhibitory effects on phosphorylation and degradation of IκBα, and on NF-κB reporter activity. In summary, these data propose that Comp has substantial anti-inflammatory properties and warrants further study concerning its potential use as a therapeutic agent for inflammation-associated maladies.

【 授权许可】

Unknown