Apo-9′-Fucoxanthinone, Isolated from Sargassum muticum, Inhibits CpG-Induced Inflammatory Response by Attenuating the Mitogen-Activated Protein Kinase Pathway

Marine Drugs

Doobyeong Chae³  Zahid Manzoor³  Sung Chun Kim²  Sohyun Kim³  Tae-Heon Oh²  Eun-Sook Yoo³  Hee-Kyoung Kang³  Jin-Won Hyun³  Nam Ho Lee²  Mi-Hee Ko¹ 

[1] Jeju Biodiversity Research Institute, Jeju Technopark, Jeju 699-943, Korea; E-Mail:;Department of Chemistry, College of Natural Sciences, Jeju National University, Jeju 690-756, Korea; E-Mails:;School of Medicine, Jeju National University, Jeju 690-756, Korea; E-Mails:

关键词: Sargassum muticum;    apo-9′-fucoxanthinone;    activator protein-1;    pro-inflammatory cytokine;    ERK1/2;    inflammation;   

DOI  :  10.3390/md11093272

来源: mdpi

【 摘 要 】

Sargassum muticum (S. muticum) is a brown edible alga and widely distributed in Korea. This report was designed to evaluate the anti-inflammatory properties of apo-9′-fucoxanthinone (APO-9′) isolated from S. muticum on pro-inflammatory cytokine production. S. muticum extract (SME) exhibited significant inhibitory effects on pro-inflammatory cytokine production in bone marrow-derived macrophages (BMDMs) and dendritic cells (BMDCs). APO-9′ pre-treatment in the CpG DNA-stimulated BMDMs and BMDCs showed a strong dose-dependent inhibitory effect on interleukin (IL)-12 p40, IL-6 and tumor necrosis factor (TNF)-α production with IC₅₀ values ranging from 5.31 to 13.79. It exhibited a strong inhibitory effect on the phosphorylation of ERK1/2 and on activator protein (AP)-1 reporter activity. APO-9′ pre-treatment exhibited significant inhibition of CpG DNA-induced production of inducible nitric oxide synthase. Taken together, these data suggest that SME and APO-9′ have a significant anti-inflammatory property and warrant further studies concerning the potentials of SME and APO-9′ for medicinal use.

【 授权许可】

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© 2013 by the authors; licensee MDPI, Basel, Switzerland.