Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts

Frontiers in Public Health

Houbing Qin¹  Shibo Ying²  Zheng Huang³  Sanying Wang⁴  Chuan Sun⁴  Xiaogang Xu⁴  Genxiang Mao⁴  Jing Zhang⁴ 

[1] Department of Respiratory Medicine, Children's Hospital of Nanjing Medical University, Nanjing, China;Hangzhou Medical College, Hangzhou, China;School of Stomatology, Hangzhou Normal University, Hangzhou, China;Zhejiang Provincial Key Lab of Geriatrics and Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou, China;

关键词: electromagnetic fields (EMFs);    aging;    DNA damage;    pulsed electromagnetic field;    cellular senescence;    human fetal lung fibroblasts;   

DOI  :  10.3389/fpubh.2021.761069

来源: DOAJ

【 摘 要 】

Rapid population aging has led to a global burden of late-life diseases. As the largest risk factor for a multitude of age-related diseases, aging is not only the result of genotype but also closely related to external factors. With the rapid expansion in the usage of electromagnetic fields (EMFs), the effect of EMFs on aging has also attracted attention. Cells are the basic unit of organs and body tissues, and cellular senescence plays an important role in the aging process. The effect of EMFs on cellular senescence has been investigated in a few studies, but the information is limited, and the results are inconsistent; thus, further investigation is required. In this study, we investigated the effect of 10 Hz pulsed magnetic fields (MFs) on cellular senescence in a 2BS cell line, isolated from human fetal lung fibroblasts, and found that intermittent (1 d on/1 d off) exposure to 10 Hz pulsed MFs at 1.0 mT for 2 weeks induced DNA damage, but no other significant phenotype of cellular senescence in 2BS cells.

【 授权许可】

Unknown