Obesity and Pancreatic Cancer: Recent Progress in Epidemiology, Mechanisms and Bariatric Surgery

Biomedicines

David A. Bernlohr¹  Masato Yamamoto²  Naohiko Nakamura²  Shuhei Shinoda²  Brett Roach²  Sayeed Ikramuddin² 

[1] Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA;Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA;

关键词: PDAC;    pancreatic cancer;    obesity;    bariatric surgery;   

DOI  :  10.3390/biomedicines10061284

来源: DOAJ

【 摘 要 】

More than 30% of people in the United States (US) are classified as obese, and over 50% are considered significantly overweight. Importantly, obesity is a risk factor not only for the development of metabolic syndrome but also for many cancers, including pancreatic ductal adenocarcinoma (PDAC). PDAC is the third leading cause of cancer-related death, and 5-year survival of PDAC remains around 9% in the U.S. Obesity is a known risk factor for PDAC. Metabolic control and bariatric surgery, which is an effective treatment for severe obesity and allows massive weight loss, have been shown to reduce the risk of PDAC. It is therefore clear that elucidating the connection between obesity and PDAC is important for the identification of a novel marker and/or intervention point for obesity-related PDAC risk. In this review, we discussed recent progress in obesity-related PDAC in epidemiology, mechanisms, and potential cancer prevention effects of interventions, including bariatric surgery with preclinical and clinical studies.

【 授权许可】

Unknown