Intraductal Papillary Mucinous Carcinoma Versus Conventional Pancreatic Ductal Adenocarcinoma: A Comprehensive Review of Clinical-Pathological Features, Outcomes, and Molecular Insights

International Journal of Molecular Sciences

Renato M. Lupinacci¹  Jean-Baptiste Bachet²  Léo Mas²  Magali Svrcek³  Jérôme Cros⁴  Florence Coulet⁵ 

[1] Department of Digestive and Oncologic Surgery, Ambroise Paré Hospital, AP-HP, 9 Avenue Charles de Gaulle, 92104 Boulogne-Billancourt, France;Department of Hepato-Gastroenterology and Digestive Oncology, Pitié Salpêtrière Hospital, APHP, 47-83 Boulevard de l’Hôpital, 75013 Paris, France;INSERM UMRS_938, Microsatellite Instability and Cancer, Saint-Antoine Research Center, SIRIC CURAMUS, Sorbonne University, 75012 Paris, France;Institut National de la Santé et de la Recherche Médicale-Centre de Recherche Biomédicale Bichat Beaujon (CRI)/INSERM U1149, 92110 Clichy, France;Sorbonne University, UPMC University, 75006 Paris, France;

关键词: pancreatic cancer;    PDAC;    precursor;    IPMN;    Intraductal papillary mucinous carcinoma;    colloid carcinomas;   

DOI  :  10.3390/ijms22136756

来源: DOAJ

【 摘 要 】

Intraductal papillary mucinous neoplasms (IPMN) are common and one of the main precursor lesions of pancreatic ductal adenocarcinoma (PDAC). PDAC derived from an IPMN is called intraductal papillary mucinous carcinoma (IPMC) and defines a subgroup of patients with ill-defined specificities. As compared to conventional PDAC, IPMCs have been associated to clinical particularities and favorable pathological features, as well as debated outcomes. However, IPMNs and IPMCs include distinct subtypes of precursor (gastric, pancreato-biliary, intestinal) and invasive (tubular, colloid) lesions, also associated to specific characteristics. Notably, consistent data have shown intestinal IPMNs and associated colloid carcinomas, defining the “intestinal pathway”, to be associated with less aggressive features. Genomic specificities have also been uncovered, such as mutations of the GNAS gene, and recent data provide more insights into the mechanisms involved in IPMCs carcinogenesis. This review synthetizes available data on clinical-pathological features and outcomes associated with IPMCs and their subtypes. We also describe known genomic hallmarks of these lesions and summarize the latest data about molecular processes involved in IPMNs initiation and progression to IPMCs. Finally, potential implications for clinical practice and future research strategies are discussed.

【 授权许可】

Unknown