Deliver Anti-inflammatory Drug Baicalein to Macrophages by Using a Crystallization Strategy

Frontiers in Chemistry

Chao Teng¹  Jianming Zhang¹  Wei He¹  Caolong Li² 

[1] School of Pharmacy, China Pharmaceutical University, Nanjing, China;School of Science, China Pharmaceutical University, Nanjing, China;Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China;

关键词: anti-inflammation;    baicalein;    macrophages;    nanocrystals;    low solubility;   

DOI  :  10.3389/fchem.2020.00787

来源: DOAJ

【 摘 要 】

Macrophages are potent to modulate inflammation via phenotypic switch and production of inflammatory factors. Baicalein (BCL) is frequently used to alleviate inflammation; however, its application is always hindered due to low solubility. Herein, BCL nanocrystals (BNRs) were prepared to improve its delivery to macrophages. The prepared BNRs have a diameter of 150 nm with a rod-like structure. The nanocrystals could be well-taken up by macrophages via the caveolar pathway and, therefore, promote the polarization switch from proinflammatory phenotype to anti-inflammatory macrophages and alleviate the inflammation via reducing production cytokine IL-12. In conclusion, the crystallization strategy is promising for the improvement of the solubility of BCL and promotion of its anti-inflammatory activities.

【 授权许可】

Unknown