Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides

Beilstein Journal of Organic Chemistry

Frank Hahn¹  Franziska Hemmerling¹ 

[1] Institut für Organische Chemie and Zentrum für Biomolekulare Wirkstoffe, Gottfried Wilhelm Leibniz Universität Hannover, Schneiderberg 38, 30167 Hannover, Germany;

关键词: biosynthesis;    chemoenzymatic synthesis;    enzymology;    heterocycles;    polyketides;   

DOI  :  10.3762/bjoc.12.148

来源: DOAJ

【 摘 要 】

This review highlights the biosynthesis of heterocycles in polyketide natural products with a focus on oxygen and nitrogen-containing heterocycles with ring sizes between 3 and 6 atoms. Heterocycles are abundant structural elements of natural products from all classes and they often contribute significantly to their biological activity. Progress in recent years has led to a much better understanding of their biosynthesis. In this context, plenty of novel enzymology has been discovered, suggesting that these pathways are an attractive target for future studies.

【 授权许可】

Unknown