Interaction of aquaporin 4 and N-methyl-D-aspartate NMDA receptor 1 in traumatic brain injury of rats

Iranian Journal of Basic Medical Sciences

Wen-De Li¹  Yi Yang¹  Li-Hua Chen¹  Hao Zhao¹  Hong-Tian Zhang¹  Kai Sun¹  Ru-Xiang Xu¹ 

[1] The Affiliated Bayi Brain Hospital, The PLA Army General Hospital,Beijing 100700, China;

关键词: Aquaporin 4;    Edema;    N-methyl-D-aspartate;    NMDA receptor;    NMDAR1;    Traumatic brain injury;   

DOI  :  10.22038/ijbms.2018.29135.7037

来源: DOAJ

【 摘 要 】

Objective(s): -methyl-D-aspartate NMDA receptor (NMDAR) and aquaporin 4 (AQP4) are involved in the molecular cascade of edema after traumatic brain injury (TBI) and are potential targets of studies in pharmacology and medicine. However, their association and interactions are still unknown.Materials and Methods: We established a rat TBI model in this study. The cellular distribution patterns of AQP4 after inhibition of NMDAR were determined by Western blotting and immunoreactive staining. Furthermore, the regulation of NMDA receptor 1 by AQP4 was studied by injection of a viral vector targeting AQP4 by RNAi into the rat brain before TBI.Results: The results suggest that AQP4 protein expression increased significantly (P

【 授权许可】

Unknown