Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights

Molecules

María Vallet-Regí¹  Montserrat Colilla¹  Isabel Izquierdo-Barba¹  Miguel Manzano¹ 

[1] Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain;

关键词: mesoporous silica nanoparticles;    multifunctional nanosystem;    selective targeting;    stimuli-responsive drug delivery;    in vitro degradation;    benefits and downsides;    clinical translation;    biosafety;   

DOI  :  10.3390/molecules23010047

来源: DOAJ

【 摘 要 】

This manuscript reviews the recent progress on mesoporous silica nanoparticles as drug delivery systems. Their intrinsic structural, textural and chemical features permit to design versatile multifunctional nanosystems with the capability to target the diseased tissue and release the cargo on demand upon exposition to internal or external stimuli. The degradation rate of these nanocarriers in diverse physiological fluids is overviewed obeying their significance for their potential translation towards clinical applications. To conclude, the balance between the benefits and downsides of this revolutionary nanotechnological tool is also discussed.

【 授权许可】

Unknown