International Journal of Infectious Diseases | |
Antibody responses after two doses of SARS-CoV-2 mRNA-1273 vaccine in an individual with history of COVID-19 re-infection | |
Kenji Maeda1  Mari Terada2  Hiroaki Mitsuya3  Noriko Iwamoto4  Mugen Ujiie5  Shinichiro Morioka6  Akihiro Matsunaga6  Masahiro Ishikane6  Satoshi Kutsuna6  Norio Ohmagari6  Yukihito Ishizaka6  Makoto Inada6  | |
[1] Center for Clinical Science, National Center for Global Health and Medicine, Tokyo, Japan;Corresponding author: Masahiro Ishikane, M.D., Ph.D., Department of Disease Control and Prevention Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.;Professor, Department of Infection Control, Graduate School of Medicine, Osaka University, Osaka, Japan;Department of Intractable Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan;Department of Refractory Viral Infections, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan;Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan; | |
关键词: COVID-19; SARS-CoV-2; re-infection; antispike protein IgG antibody; neutralizing antibody; vaccine; | |
DOI : | |
来源: DOAJ |
【 摘 要 】
We present a case of a 58-year-old Japanese man with a history of 2 previous COVID-19 infections, who received 2 doses of mRNA-1273 vaccine. We are not aware of any previous study regarding antibody tendency after 2 infections and 2 vaccinations. We evaluated his IgG titer of antispike protein and neutralizing activity from the first infection before and after 2 doses of vaccine. Both antispike IgG titer and neutralizing activity showed a tendency to decline almost 1 year after initial infection; they rapidly increased after the first vaccination, and they remained high after the second vaccination. Although this is a single case report, it seems to have generalizability because the findings are consistent with previous reports regarding single infections or 3 doses of vaccination. Our findings suggest that a single booster shot may provide sufficient protection and aid the understanding of immunologic responses of vaccination in patients with COVID-19 with history of re-infection.
【 授权许可】
Unknown