Antibody responses after two doses of SARS-CoV-2 mRNA-1273 vaccine in an individual with history of COVID-19 re-infection

International Journal of Infectious Diseases

Kenji Maeda¹  Mari Terada²  Hiroaki Mitsuya³  Noriko Iwamoto⁴  Mugen Ujiie⁵  Shinichiro Morioka⁶  Akihiro Matsunaga⁶  Masahiro Ishikane⁶  Satoshi Kutsuna⁶  Norio Ohmagari⁶  Yukihito Ishizaka⁶  Makoto Inada⁶ 

[1] Center for Clinical Science, National Center for Global Health and Medicine, Tokyo, Japan;Corresponding author: Masahiro Ishikane, M.D., Ph.D., Department of Disease Control and Prevention Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.;Professor, Department of Infection Control, Graduate School of Medicine, Osaka University, Osaka, Japan;Department of Intractable Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan;Department of Refractory Viral Infections, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan;Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan;

关键词: COVID-19;    SARS-CoV-2;    re-infection;    antispike protein IgG antibody;    neutralizing antibody;    vaccine;   

DOI  :  

来源: DOAJ

【 摘 要 】

We present a case of a 58-year-old Japanese man with a history of 2 previous COVID-19 infections, who received 2 doses of mRNA-1273 vaccine. We are not aware of any previous study regarding antibody tendency after 2 infections and 2 vaccinations. We evaluated his IgG titer of antispike protein and neutralizing activity from the first infection before and after 2 doses of vaccine. Both antispike IgG titer and neutralizing activity showed a tendency to decline almost 1 year after initial infection; they rapidly increased after the first vaccination, and they remained high after the second vaccination. Although this is a single case report, it seems to have generalizability because the findings are consistent with previous reports regarding single infections or 3 doses of vaccination. Our findings suggest that a single booster shot may provide sufficient protection and aid the understanding of immunologic responses of vaccination in patients with COVID-19 with history of re-infection.

【 授权许可】

Unknown