A Journey into the Clinical Relevance of Heme Oxygenase 1 for Human Inflammatory Disease and Viral Clearance: Why Does It Matter on the COVID-19 Scene?

Antioxidants

Pablo Sanchis¹  Rocio Seniuk¹  Ayelen Toro¹  Sofia Lage-Vickers¹  Felipe Vilicich¹  Elba Vazquez¹  Agustina Sabater¹  Florencia Cascardo¹  Sabrina Ledesma-Bazan¹  María Sol Ruiz¹  Geraldine Gueron¹  Gaston Pascual¹ 

[1] Laboratorio de Inflamación y Cáncer, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EGA, Argentina;

关键词: heme oxygenase 1;    COVID-19;    influenza A virus;    respiratory syncytial virus;    human immunodeficiency virus;    Ebola virus;   

DOI  :  10.3390/antiox11020276

来源: DOAJ

【 摘 要 】

Heme oxygenase 1 (HO-1), the rate-limiting enzyme in heme degradation, is involved in the maintenance of cellular homeostasis, exerting a cytoprotective role by its antioxidative and anti-inflammatory functions. HO-1 and its end products, biliverdin, carbon monoxide and free iron (Fe²⁺), confer cytoprotection against inflammatory and oxidative injury. Additionally, HO-1 exerts antiviral properties against a diverse range of viral infections by interfering with replication or activating the interferon (IFN) pathway. Severe cases of coronavirus disease 2019 (COVID-19), an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are characterized by systemic hyperinflammation, which, in some cases, leads to severe or fatal symptoms as a consequence of respiratory failure, lung and heart damage, kidney failure, and nervous system complications. This review summarizes the current research on the protective role of HO-1 in inflammatory diseases and against a wide range of viral infections, positioning HO-1 as an attractive target to ameliorate clinical manifestations during COVID-19.

【 授权许可】

Unknown