Long-Term Surgical Outcomes of Liver Resection for Hepatocellular Carcinoma in Patients With HBV and HCV Co-Infection: A Multicenter Observational Study

Frontiers in Oncology

Ting-Hao Chen¹  Zhi-Yu Chen²  Jian-Hong Zhong³  Wan Yee Lau⁴  Timothy M. Pawlik⁵  Hong Wang⁶  Xin-Ping Fan⁷  Wan-Guang Zhang⁸  Cheng-Wu Zhang⁹  Feng Shen^1,10  Chao Li^1,10  Han Wu^1,10  Tian Yang^1,10  Ya-Hao Zhou^1,11  Ying-Jian Liang^1,12  Qiu-Ran Xu^1,13  Dong-Sheng Huang^1,13  Hang-Dong Jia^1,13  Yong-Kang Diao^1,13  Lei Liang^1,13  Wei-Min Gu^1,14 

[1] 0Department of General Surgery, Ziyang First People’s Hospital, Sichuan, China;1Department of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China;2Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China;3Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China;4Department of Surgery, Ohio State University, Wexner Medical Center, Columbus, OH, United States;Department of General Surgery, Liuyang People’s Hospital, Hunan, China;Department of General Surgery, Pingxiang Mining Group General Hospital, Jiangxi, China;Department of Hepatic Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China;Department of Hepatobiliary Pancreatic and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital (People’s Hospital of Hangzhou Medical College), Hangzhou, China;Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Navy Medical University), Shanghai, China;Department of Hepatobiliary Surgery, Pu’er People’s Hospital, Yunnan, China;Department of Hepatobiliary Surgery, The First Affiliated Hospital of Harbin Medical University, Heilongjiang, China;School of Clinical Medicine, Hangzhou Medical College, Hangzhou, China;The First Department of General Surgery, The Fourth Hospital of Harbin, Heilongjiang, China;

关键词: hepatocellular carcinoma;    hepatectomy;    hepatitis B virus;    hepatitis C virus;    overall survival;    recurrence-free survival;   

DOI  :  10.3389/fonc.2021.700228

来源: DOAJ

【 摘 要 】

BackgroundHepatocellular carcinoma (HCC) is one of the most serious consequences of chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. This study sought to investigate long-term outcomes after liver resection for HCC among patients with HBV/HCV co-infection (HBV/HCV-HCC) compared with patients with HBV infection (HBV-HCC).MethodsPatients who underwent curative-intent liver resection for HCC were identified from a multicenter Chinese database. Using propensity score matching (PSM), patients with HBV/HCV-HCC were matched one-to-one to patients with HBV-HCC. Overall survival (OS) and recurrence-free survival (RFS) were compared between the two groups before and after PSM.ResultsAmong 2,467 patients identified, 93 (3.8%) and 2,374 (96.2%) patients had HBV/HCV-HCC and HBV-HCC, respectively. Compared with patients with HBV-HCC, patients with HBV/HCV-HCC were older, have poorer liver-related characteristics but better tumor-related characteristics. PSM created 88 pairs of patients with comparable liver- and tumor-related characteristics (all P > 0.2). In the PSM cohort, the 3- and 5-year RFS rates in patients with HBV/HCV-HCC were 48.3% and 38.9%, which were significantly poorer than patients with HBV-HCC (61.8% and 49.2%, P = 0.037). Meanwhile, the 3- and 5-year OS rates in patients with HBV/HCV-HCC were also poorer than patients with HBV-HCC (65.4% and 51.1% vs. 73.7% and 63.0%), with a difference close to be significant between them (P = 0.081).ConclusionComparing to patients with HBV-HCC, liver resection resulted in relatively poorer long-term surgical outcomes in patients with HBV/HCV-HCC.

【 授权许可】

Unknown