c-MYC—Making Liver Sick: Role of c-MYC in Hepatic Cell Function, Homeostasis and Disease

Genes

Francisco Javier Cubero¹  Kang Zheng¹  Yulia A. Nevzorova² 

[1] Department of Immunology, Complutense University School of Medicine, Plaza Ramón y Cajal s/n, Madrid 28040, Spain;Department of Internal Medicine III, University Hospital RWTH, Aachen 52074, Germany;

关键词: c-Myc Avian Myelocytomatosis Viral Oncogene Homolog;    hepatocellular carcinoma;    alcoholic liver disease;    hepatoblastoma;    hepatitis B virus;    hepatitis C virus;    Liver;   

DOI  :  10.3390/genes8040123

来源: DOAJ

【 摘 要 】

Over 35 years ago, c-MYC, a highly pleiotropic transcription factor that regulates hepatic cell function, was identified. In recent years, a considerable increment in the number of publications has significantly shifted the way that the c-MYC function is perceived. Overexpression of c-MYC alters a wide range of roles including cell proliferation, growth, metabolism, DNA replication, cell cycle progression, cell adhesion and differentiation. The purpose of this review is to broaden the understanding of the general functions of c-MYC, to focus on c-MYC-driven pathogenesis in the liver, explain its mode of action under basal conditions and during disease, and discuss efforts to target c-MYC as a plausible therapy for liver disease.

【 授权许可】

Unknown