Dynamic Neuroimmune Profile during Mid-life Aging in the Female Brain and Implications for Alzheimer Risk

iScience

Fei Yin¹  Yiwei Wang¹  Aarti Mishra¹  Yuan Shang¹  Roberta D. Brinton¹  Eliza R. Bacon² 

[1] Center for Innovation in Brain Science, University of Arizona, Tucson, AZ 85719, USA;Department of Medical Oncology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA;

关键词: Neuroscience;    Immunology;    Endocrinology;    Transcriptomics;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: Aging and endocrine transition states can significantly impact inflammation across organ systems. Neuroinflammation is well documented in Alzheimer disease (AD). Herein, we investigated neuroinflammation that emerges during mid-life aging, chronological and endocrinological, in the female brain as an early initiating mechanism driving AD risk later in life. Analyses were conducted in a translational rodent model of mid-life chronological and endocrinological aging followed by validation in transcriptomic profiles from women versus age-matched men. In the translational model, the neuroinflammatory profile of mid-life aging in females was endocrine and chronological state specific, dynamic, anatomically distributed, and persistent. Microarray dataset analyses of aging human hippocampus indicated a sex difference in neuroinflammatory profile in which women exhibited a profile comparable to the pattern discovered in our translational rodent model, whereas age-matched men exhibited a profile consistent with low neuroimmune activation. Translationally, these findings have implications for therapeutic interventions during mid-life to decrease late-onset AD risk.

【 授权许可】

Unknown