Estrous cycle and ovariectomy-induced changes in visceral pain are microbiota-dependent

iScience

Patrick Fitzgerald¹  John F. Cryan²  Siobhain M. O’ Mahony³  James M. Collins³  Mónica Tramullas³  Timothy G. Dinan³ 

[1] Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland;Department of Psychiatry and Behavioural Science, University College Cork, Cork, Ireland;APC Microbiome Ireland, University College Cork, Cork, Ireland;

关键词: Endocrinology;    Microbiome;    Neuroscience;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: Visceral hypersensitivity (VH) is a hallmark of many functional gastrointestinal disorders including irritable bowel syndrome and is categorized by a dull, diffuse sensation of abdominal pain. Recently, the gut microbiota has been implicated in VH in male mice, but the effects in females have yet to be explored fully. To this end, we now show that somewhat surprisingly, female germ-free mice have similar visceral pain responses to colorectal distension (CRD) as their conventional controls. However, we show that although sensitivity to CRD is estrous cycle stage-dependent in conventional mice, it is not in germ-free mice. Further, ovariectomy (OVX) induced VH in conventional but not germ-free mice, and induced weight gain regardless of microbiota status. Finally, we show that estrogen-replacement ameliorated OVX-induced VH. Taken together, this study provides evidence for a major role of female sex hormones and the gut microbiota in sensation of visceral pain in females.

【 授权许可】

Unknown