Zinc Affects Cholesterol Oxidation Products and Fatty Acids Composition in Rats’ Serum

Nutrients

Robert Wrzesień¹  Rafał Wyrębiak²  Agnieszka Stawarska³  Małgorzata Czerwonka³  Barbara Bobrowska-Korczak³ 

[1] Central Laboratory of Experimental Animals, Medical University of Warsaw, Poland, Banacha 1a, 02-091 Warsaw, Poland;Department of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland;Department of Bromatology, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland;

关键词: zinc;    fatty acids;    Δ6- and Δ5–desaturase;    cholesterol;    oxysterols;   

DOI  :  10.3390/nu13051563

来源: DOAJ

【 摘 要 】

The purpose of this work was to evaluate the effect of the nanosized or microsized zinc (Zn) particles on fatty acid profile, enzyme activity and the level of cholesterol, squalene and oxysterols in rats with breast cancer. Rats (female, n = 24) were divided into the following groups: control, and two test groups, whose diets were enriched with either Zn microparticles (342 nm) or Zn nanoparticles (99 nm). All rats were treated twice with the carcinogenic agent; 7,12-dimethylbenz[a]anthracene. In rats whose diet was enriched with zinc (especially in the form of nanoparticles), the number and sizes of tumors were lower. Diet supplementation also significantly reduced the cholesterol (p = 0.027) and COPs (cholesterol oxidation products) levels (p = 0.011) in rats serum. Enriching the diet with Zn microparticles decreased the Δ6-desaturase activity (p < 0.001). Zn influences fatty acids’ profile in rats’ serum as well as inhibiting desaturating enzymes. A reduced amount of pro-inflammatory arachidonic acid derivatives may be the expected effect.

【 授权许可】

Unknown