Antimicrobial Resistance in Salmonella Isolated from Food Workers and Chicken Products in Japan

Antibiotics

Masaru Yonemichi¹  Yukari Haremaki¹  Tetsuo Asai²  Tetsuya Ikeda³  Yoshimasa Sasaki⁴  Hiroshi Asakura⁴  Kenji Ohya⁵  Yukiko Hara-Kudo⁵  Youichi Baba⁶  Takeshi Ito⁶  Hiromi Kakizawa⁶  Makoto Kuroda⁷ 

[1] BML Food Science Solutions, Inc., 1549-7, Matoba, Kawagoe 350-1101, Saitama, Japan;Department of Applied Veterinary Science, The United Graduate School of Veterinary Science, Gifu University, 1-1, Yanagido, Gifu 501-1193, Gifu, Japan;Department of Infectious Diseases, Hokkaido Institute of Public Health, Kita19 Nishi 12, Kita-ku, Sapporo 060-0819, Hokkaido, Japan;Division of Biomedical Food Research, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki 210-9501, Kanagawa, Japan;Division of Microbiology, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki 210-9501, Kanagawa, Japan;Incorporated Foundation Tokyo Kenbikyo-in, 1-100-38 Takamatsu-cho, Tachikawa 190-0011, Tokyo, Japan;Pathogen Genomics Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan;

关键词: antimicrobial resistance;    Salmonella;    food worker;    chicken product;   

DOI  :  10.3390/antibiotics10121541

来源: DOAJ

【 摘 要 】

Salmonella is an enteric bacterial pathogen that causes foodborne illness in humans. Third-generation cephalosporin (TGC) resistance in Salmonella remains a global concern. Food workers may represent a reservoir of Salmonella, thus potentially contaminating food products. Therefore, we aimed to investigate the prevalence of Salmonella in food workers and characterize the isolates by serotyping and antimicrobial susceptibility testing. Salmonella was isolated from 583 (0.079%) of 740,635 stool samples collected from food workers between January and December 2018, and then serotyped into 76 Salmonella enterica serovars and 22 untypeable Salmonella strains. High rates of antimicrobial resistance were observed for streptomycin (51.1%), tetracycline (33.1%), and kanamycin (18.4%). Although isolates were susceptible to ciprofloxacin, 12 (2.1%) strains (one S. Infantis, one S. Manhattan, two S. Bareilly, two S. Blockley, two S. Heidelberg, two S. Minnesota, one S. Goldcoast, and one untypeable Salmonella strain) were resistant to the TGC cefotaxime, all of which harbored β-lactamase genes (bla_CMY-2, bla_CTX-M-15, bla_CTX-M-55, and bla_TEM-52B). Moreover, 1.3% (4/309) of Salmonella strains (three S. Infantis and one S. Manhattan strains) isolated from chicken products were resistant to cefotaxime and harbored bla_CMY-2 or bla_TEM-52B. Thus, food workers may acquire TGC-resistant Salmonella after the ingestion of contaminated chicken products and further contaminate food products.

【 授权许可】

Unknown