Prognostic role of HSPs in human gastrointestinal cancer: a systematic review and meta-analysis

OncoTargets and Therapy

关键词: Heat shock protein Gastrointestinal cancer;    Prognosis;    Meta-analysis.;   

DOI  :  

来源: DOAJ

【 摘 要 】

Hua Ge,1 Yan Yan,2 Lingfei Guo,1 Fei Tian,1 Di Wu11Department of Gastrointestinal Surgery, 2Quality Control Department, The First People’s Hospital of Zunyi, Zunyi Medical University, Huichuan, Zunyi, Guizhou, ChinaBackground: Heat shock proteins (HSPs) have been reported to be overexpressed in a wide range of human tumors. It has been shown that HSPs act as an oncogenic regulator and are involved in tumorigenesis. The clinical and prognostic significance of HSPs in gastrointestinal cancers (GICs) remains controversial. The aim of this study was to conduct a meta-analysis to assess the prognostic value of HSPs in GICs. Materials and methods: A literature search was performed in PubMed, Cochrane Library, Web of Science, and Embase databases. Data on the relationship between expression of HSPs and survival outcomes were extracted. Pooled hazard ratios (HRs) with 95% CI were calculated.Results: The expression of HSPs was not associated with the overall survival (OS) of GIC patients; however, it was significantly associated with worse OS for gastric cancer (GC) and colorectal cancer (CRC) patients.Conclusion: Current evidence suggests that a high level of HSPs may not be a potential marker to predict the survival rate for every type of GICs. However, the expression of HSPs may predict a poor prognosis for GC and CRC patients.Keywords: heat shock protein, gastrointestinal cancer, prognosis, meta-analysis 

【 授权许可】

Unknown