Long-term exposure to road traffic noise and stroke incidence: a Danish Nurse Cohort study

Environmental Health

Claus Backalarz¹  Amar Mehta²  Ole Hertel³  Jesper H. Christensen⁴  Lise M. Frohn⁴  Matthias Ketzel⁴  Steen Solvang Jensen⁴  Camilla Geels⁴  Jørgen Brandt⁴  Elvira V. Bräuner⁵  Mette K. Simonsen⁶  Jeanette T. Jørgensen⁷  Steffen Loft⁷  Zorana J. Andersen⁷  Heresh Amini⁷  Youn-Hee Lim⁷  Shuo Li⁷  Tom Cole-Hunter⁷  Rina So⁷  Barbara Hoffmann⁸  Laust H. Mortensen⁹  Rudi Westendorp⁹  Christian Dehlendorff^1,10 

[1] DELTA Acoustics;Denmark Statistics;Department of Bioscience, Aarhus University;Department of Environmental Science, Aarhus University;Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen;Diakonissestiftelsen;Environmental Epidemiology Group, Section of Environmental Health, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen;Institute for Occupational, Social and Environmental Medicine, Centre for Health and Society, Medical Faculty, Heinrich-Heine-University of Düsseldorf;Section of Epidemiology, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen;Statistics and Data Analysis, Danish Cancer Society Research Center;

关键词: Road traffic noise;    Air pollution;    NO2;    PM2.5;    PM10;    Stroke;   

DOI  :  10.1186/s12940-021-00802-2

来源: DOAJ

【 摘 要 】

Abstract Background Road traffic noise has been linked to increased risk of ischemic heart disease, yet evidence on stroke shows mixed results. We examine the association between long-term exposure to road traffic noise and incidence of stroke, overall and by subtype (ischemic or hemorrhagic), after adjustment for air pollution. Methods Twenty-five thousand six hundred and sixty female nurses from the Danish Nurse Cohort recruited in 1993 or 1999 were followed for stroke-related first-ever hospital contact until December 31st, 2014. Full residential address histories since 1970 were obtained and annual means of road traffic noise (Lden [dB]) and air pollutants (particulate matter with diameter < 2.5 μm and < 10 μm [PM2.5 and PM10], nitrogen dioxide [NO2], nitrogen oxides [NOx]) were determined using validated models. Time-varying Cox regression models were used to estimate hazard ratios (HR) (95% confidence intervals [CI]) for the associations of one-, three-, and 23-year running means of Lden preceding stroke (all, ischemic or hemorrhagic), adjusting for stroke risk factors and air pollutants. The World Health Organization and the Danish government’s maximum exposure recommendations of 53 and 58 dB, respectively, were explored as potential Lden thresholds. Results Of 25,660 nurses, 1237 developed their first stroke (1089 ischemic, 148 hemorrhagic) during 16 years mean follow-up. For associations between a 1-year mean of Lden and overall stroke incidence, the estimated HR (95% CI) in the fully adjusted model was 1.06 (0.98–1.14) per 10 dB, which attenuated to 1.01 (0.93–1.09) and 1.00 (0.91–1.09) in models further adjusted for PM2.5 or NO2, respectively. Associations for other exposure periods or separately for ischemic or hemorrhagic stroke were similar. There was no evidence of a threshold association between Lden and stroke. Conclusions Long-term exposure to road traffic noise was suggestively positively associated with the risk of overall stroke, although not after adjusting for air pollution.

【 授权许可】

Unknown