Mediation role of cardiorespiratory fitness on the association between fatness and cardiometabolic risk in European adolescents: The HELENA study

Journal of Sport and Health Science

Javier Courel-Ibáñez¹  Jérémy Vanhelst²  Angela Polito³  Francisco B. Ortega⁴  Alba Santaliestra-Pasias⁵  Carlos Cristi-Montero⁶  Jonatan R. Ruiz⁷  Luis M. Moreno⁸  Ascensión Marcos⁹  Jose Castro-Piñero^1,10 

[1] Corresponding author.;Growth, Exercise, Nutrition and Development (GENUD) Research Group, Zaragoza 50001, Spain;Department of Health and Human Performance, School of Health Sciences, University of Zaragoza, Zaragoza 50001, Spain;Department of Physical Activity and Sport, Faculty of Sport Sciences, University of Murcia, Murcia 30071, Spain;Department of Physical Education, Faculty of Education Sciences, University of Cádiz, Puerto Real 11003, Spain;IRyS Group, Physical Education School, Pontificia Universidad Católica de Valparaíso, Valparaíso 2530388, Chile;Immunonutrition Research Group, Department Metabolism and Nutrition, Institute of Food Science and Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), Madrid E-28040 Spain;Lille Inflammation Research International Center, University of Lille, Lille 59000, France;National Institute for Food and Nutrition Research, Rome 80070, Italy;PROmoting FITness and Health through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada 18001, Spain;

关键词: Cardiovascular disease;    Children;    Fat mass;    Fitness;    Health;    Physical activity;   

DOI  :  

来源: DOAJ

【 摘 要 】

Purpose: This study was aimed to analyze the mediation role of cardiorespiratory fitness (CRF) on the association between fatness and cardiometabolic risk scores (CMRs) in European adolescents. Methods: A cross-sectional study was conducted in adolescents (n = 525; 46% boys; 14.1 ± 1.1 years old, mean ± SD) from 10 European cities involved in the Healthy Lifestyle in Europe by Nutrition in Adolescence study. CRF was measured by means of the shuttle run test, while fatness measures included body mass index (BMI), waist to height ratio, and fat mass index estimated from skinfold thicknesses. A clustered CMRs was computed by summing the standardized values of homeostasis model assessment, systolic blood pressure, triglycerides, total cholesterol/high-density lipoprotein cholesterol ratio, and leptin. Results: Linear regression models indicated that CRF acted as an important and partial mediator in the association between fatness and CMRs in 12–17-year-old adolescents (for BMI: coefficients of the indirect role β = 0.058 (95% confidence interval (95%CI): 0.023–0.101), Sobel test z = 3.11 (10.0% mediation); for waist to height ratio: β = 4.279 (95%CI: 2.242–7.059), z =3.86 (11.5% mediation); and for fat mass index: β = 0.060 (95%CI: 0.020–0.106), z = 2.85 (9.4% mediation); all p < 0.01). Conclusion: In adolescents, the association between fatness and CMRs could be partially decreased with improvements to fitness levels; therefore, CRF contribution both in the clinical field and public health could be important to consider and promote in adolescents independently of their fatness levels.

【 授权许可】

Unknown