Polysaccharide from tuberous roots of Ophiopogon japonicus regulates gut microbiota and its metabolites during alleviation of high-fat diet-induced type-2 diabetes in mice

Journal of Functional Foods

Cheng Wang¹  Karl W.K. Tsim¹  Lin-Xiu Guo¹  Wei-Hui Hu²  Zhi-Tian Peng³  Huai-You Wang³  Etta Y.L. Liu³  Zhi-Cong Chen³  Tie-Jie Wang³  Tina T.X. Dong³ 

[1] Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China;Shenzhen Key Laboratory of Drug Quality Standard Research, Shenzhen Institute for Drug Control, Shenzhen 518057, China;Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Shenzhen 518057, China;

关键词: Ophiopogon japonicus;    Polysaccharides;    Type-2 diabetes;    Gut microbiota;    Short-chain fatty acids;   

DOI  :  

来源: DOAJ

【 摘 要 】

Ophiopogonis Radix (Maidong in Chinese), the tuberous roots of Ophiopogon japonicus having polysaccharide as the main active ingredient, is a traditional Chinese herb and popularly used as functional food additive in China. Here, a homogeneous polysaccharide fraction (OJP-W1) was isolated and characterized from Ophiopogonis Radix collected from Sichuan (Chuan-Maidong). The therapeutic effects of OJP-W1 in diabetes symptoms, gut microbiota and metabolism of short-chain fatty acids (SCFAs) in high-fat diet (HFD)-induced type-2 diabetes mice were investigated. Results showed that OJP-W1 significantly ameliorated HFD-induced insulin resistance and glucose tolerance. Meanwhile, OJP-W1 regulated the gut microbiota dysbiosis in HFD-fed mice, as indicated by increasing Actinobacteria and Bifidobacterium, decreasing Proteobacteria and type-2 diabetes-enriched taxa (e.g. Desulfovibrionaceae, Dorea and Ruminococcaceae). In addition, OJP-W1 could improve the metabolic disorder of SCFAs in HFD-fed mice. This study indicated that OJP-W1 might serve as a novel functional food in preventing diabetes-associated gut microbiota dysbiosis and SCFA metabolic disorder.

【 授权许可】

Unknown