Haemophagocytic lymphohistiocytosis in patients with human immunodeficiency virus infection: to treat or not to treat

The Pan African Medical Journal

Naval Kishore Vikram¹  Farhan Fazal¹  Aditya Nayan¹  Shivabalan Kathavarayan Ramu¹  Nitin Gupta¹  Animesh Ray¹ 

[1] Department of Medicine, All India Institute of Medical Sciences, New Delhi, India;

关键词: malignancy;    steroids;    hospital acquired pneumonia;   

DOI  :  10.11604/pamj.2019.32.105.14764

来源: DOAJ

【 摘 要 】

Haemophagocytic lymphohistiocytosis (HLH) in Human Immunodeficiency Virus (HIV) infected individuals can either be due to the disease itself or due to associated infections/malignancies. The treatment for HLH requires immunosuppressive therapy but administering immunosuppressive therapy to an already immunosuppressed patient (HIV infection) is complex. We present two such cases of HLH in patients infected with HIV. In the first case, no alternate cause for HLH was found even after extensive investigations and it was attributed to the uncontrolled HIV replication. Patient was started on dexamethasone for the same but succumbed to hospital acquired pneumonia. The second patient was diagnosed with Hodgkin's lymphoma but he succumbed to his illness before initiating immunosuppressive therapy for HLH. We report these cases to highlight the dilemma and a need for further research in this direction.

【 授权许可】

Unknown