Metabolic and Anti-Inflammatory Protective Properties of Human Enriched Serum Following Artichoke Leaf Extract Absorption: Results from an Innovative Ex Vivo Clinical Trial

Nutrients

Véronique Roux¹  Gisèle Pickering¹  Nicolas Macian¹  Stéphane Descamps²  Fabien Wauquier³  Line Boutin-Wittrant³  Gwladys Charpentier⁴  Asma Bourafai-Aziez⁴  Emmanuel Cassin⁴  Guillaume Rousselot⁴  Yohann Wittrant⁵  Aurélien Viret⁶  Laure Guilhaudis⁶  Hassan Oulyadi⁶ 

[1] CIC INSERM 1405/Plateforme d’Investigation Clinique CHU Gabriel Montpied, 58 Rue Montalembert, CEDEX 1, F-63000 Clermont-Ferrand, France;CNRS, CHU Clermont Ferrand, ICCF, Clermont Auvergne INP, Université Clermont Auvergne, CEDEX 1, F-63000 Clermont-Ferrand, France;Clinic’n’Cell SAS, Faculty of Medicine and Pharmacy, TSA 50400, 28 Place Henri Dunant, CEDEX 1, F-63001 Clermont-Ferrand, France;EVEAR EXTRACTION, 48 Route de Gennes, LD Félines, CEDEX 4, 49320 Coutures, France;INRAE, UMR 1019, UNH, CEDEX 1, F-63009 Clermont-Ferrand, France;Laboratoire COBRA (UMR 6014 & FR 3038), CNRS, INSA de Rouen, UNIROUEN, Normandie Université, F-76821 Mont-Saint-Aignan, France;

关键词: clinical trial;    metabolic disorders;    inflammation;    artichoke;    polyphenols;    metabolites;   

DOI  :  10.3390/nu13082653

来源: DOAJ

【 摘 要 】

The aging of our population is accompanied by an increased prevalence of chronic diseases. Among those, liver, joint and adipose tissue-related pathologies have a major socio-economic impact. They share common origins as they result from a dysregulation of the inflammatory and metabolic status. Plant-derived nutrients and especially polyphenols, exert a large range of beneficial effects in the prevention of chronic diseases but require clinically validated approaches for optimized care management. In this study, we designed an innovative clinical approach considering the metabolites produced by the digestive tract following the ingestion of an artichoke leaf extract. Human serum, enriched with metabolites deriving from the extract, was collected and incubated with human hepatocytes, human primary chondrocytes and adipocytes to determine the biological activity of the extract. Changes in cellular behavior demonstrated that the artichoke leaf extract protects hepatocytes from lipotoxic stress, prevents adipocytes differentiation and hyperplasia, and exerts chondroprotective properties in an inflammatory context. These data validate the beneficial health properties of an artichoke leaf extract at the clinical level and provide both insights and further evidence that plant-derived nutrients and especially polyphenols from artichoke may represent a relevant alternative for nutritional strategies addressing chronic disease issues.

【 授权许可】

Unknown