Characterization of natural killer cells in tamarins: a technical basis for studies of innate immunity

Frontiers in Microbiology

Yuko eKatakai¹  Keith A Reimann²  Toshiyuki eHayakawa³  Tomoyuki eYoshida⁴  Terue eKurosawa⁴  Yasuhiro eYasutomi⁴  Sayuki eIijima⁴  Hirofumi eAkari⁴  Akatsuki eSaito⁵  Yuki eIwasaki⁶ 

[1] Corporation for Production and Research of Laboratory Primates;Harvard Medical School;Kyoto University;National Institute of Biomedical Innovation;The University of Tokyo;Tokyo Medical and Dental University;

关键词: NK cell;    CD16;    cynomolgus monkey;    tamarin;   

DOI  :  10.3389/fmicb.2010.00128

来源: DOAJ

【 摘 要 】

Natural killer (NK)cells are capable of regulating viral infection without major histocompatibility complex restriction. Hepatitis C is caused by chronic infection with hepatitis C virus (HCV), and impaired activity of NK cells may contribute to the control of the disease progression, although the involvement of NK cells in vivo remains to be proven. GB virus B (GBV-B), which is genetically most closely related to HCV, induces acute and chronic hepatitis upon experimental infection of tamarins. This non-human primate model seems likely to be useful for unveiling the roles of NK cells in vivo. Here we characterized the biological phenotypes of NK cells in tamarins and found that depletion of the CD16+ subset in vivo by administration of a monoclonal antibody significantly reduced the number and activity of natural killer cells.

【 授权许可】

Unknown