Memory-Like NK Cells: Remembering a Previous Activation by Cytokines and NK Cell Receptors

Frontiers in Immunology

Adelheid Cerwenka¹  Jens H. W. Pahl¹  Jing Ni² 

[1] Department for Immunobiochemistry, Universitätsmedizin Mannheim, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Germany;Innate Immunity, German Cancer Consortium, German Cancer Research Center (DKFZ), Heidelberg, Germany;

关键词: memory;    NK cell;    IL-12 cytokines;    IL-12/15/18;    CD16;    recall (memory);   

DOI  :  10.3389/fimmu.2018.02796

来源: DOAJ

【 摘 要 】

Natural Killer (NK) cells are cytotoxic innate lymphoid cells serving at the front line against infection and cancer. In inflammatory microenvironments, multiple soluble and contact-dependent signals modulate NK cell responsiveness. Besides their innate cytotoxic and immunostimulatory activity, it has been uncovered in recent years that NK cells constitute a heterogeneous and versatile cell subset. Persistent memory-like NK populations that mount a robust recall response were reported during viral infection, contact hypersensitivity reactions, and after stimulation by pro-inflammatory cytokines or activating receptor pathways. In this review, we highlight recent findings on the generation, functionality, and clinical applicability of memory-like NK cells and describe common features in comparison to other recent concepts of memory NK cells. Understanding of these features will facilitate the conception and design of novel NK cell-based immunotherapies.

【 授权许可】

Unknown