Marine and Agro-Industrial By-Products Valorization Intended for Topical Formulations in Wound Healing Applications

Materials

Bogdan Negreanu-Pirjol¹  Ticuta Negreanu-Pirjol¹  Ugo D’Amora²  Lucia Moldovan³  Andreea Iosageanu³  Ana-Maria Prelipcean³  Oana Craciunescu³  Alexandra Gaspar-Pintiliescu³  Mariana Marin⁴  Raul-Augustin Mitran⁴ 

[1] Faculty of Pharmacy, University “Ovidius” of Constanta, 1 Aleea Universității, 900470 Constanta, Romania;Institute of Polymers, Composites and Biomaterials, National Research Council, 80125 Naples, Italy;National Institute of R&D for Biological Sciences, 296 Splaiul Independentei, 060031 Bucharest, Romania;“Ilie Murgulescu” Institute of Physical Chemistry, Romanian Academy, 202 Splaiul Indepedentei, 060021 Bucharest, Romania;

关键词: Rapana venosa compounds;    Cladophora vagabunda;    grape pomace;    marine and agro-industrial by-products valorization;    wound healing;    topical formulations;   

DOI  :  10.3390/ma15103507

来源: DOAJ

【 摘 要 】

Over the past years, research attention has been focusing more on waste-derived, naturally derived, and renewable materials, in the view of a more sustainable economy. In this work, different topical formulations were obtained from the valorization of marine and agro-industrial by-products and the use of Carbopol 940 as gelling agent. In particular, the combination of extracts obtained from the marine snail, Rapanosa venosa, with Cladophora vagabunda and grape pomace extracts, was investigated for wound healing purposes. Rapana venosa has demonstrated wound healing properties and antioxidant activity. Similarly, grape pomace extracts have been shown to accelerate the healing process. However, their synergic use has not been explored yet. To this aim, four different formulations were produced. Three formulations differed for the presence of a different extract of Rapana venosa: marine collagen, marine gelatin, and collagen hydrolysate, while another formulation used mammalian gelatin as further control. Physico-chemical properties of the extracts as well as of the formulations were analyzed. Furthermore, thermal stability was evaluated by thermogravimetric analysis. Antioxidant capacity and biological behavior, in terms of cytocompatibility, wound healing, and antimicrobial potential, were assessed. The results highlighted for all the formulations (i) a good conservation and thermal stability in time, (ii) a neutralizing activity against free radicals, (iii) and high degree of cytocompatibility and tissue regeneration potential. In particular, collagen, gelatin, and collagen hydrolysate obtained from the Rapana venosa marine snail represent an important, valuable alternative to mammalian products.

【 授权许可】

Unknown